Azathioprine
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Azathioprine Hypersensitivity with granulomatous septal panniculitis: case report A 52-year-old woman, with a long-term history of Crohn’s disease, developed a hypersensitivity reaction with granulomatous septal panniculitis during treatment with azathioprine. The woman developed a rash on her trunk and limbs, and felt systemically unwell with fever, myalgia and nausea, within 2 weeks of starting oral azathioprine 50mg twice daily. Five days after the development of the rash, numerous erythematous papules were evident on her upper anterior chest. On her limbs, tumid dermal lesions were apparent, clinically resembling erythema nodosum. An incisional biopsy of a thigh lesion revealed a mild lymphocytic infiltrate around the upper dermal vessels. In the subdermis, a predominantly septal panniculitis with granuloma formation was evident; some lymphocytic infiltration of vessels was apparent. Azathioprine was discontinued and, within 1 week, the woman’s symptoms and rash had resolved. Orpin S, et al. Granulomatous septal panniculitis as part of a hypersensitivity reaction to azathioprine. British Journal of Dermatology 159 (Suppl. 1): 62 abstr. 801121555 P-82, Jul 2008 - England
0114-9954/10/1215-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Reactions 16 Aug 2008 No. 1215
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