B Cell Receptor Signaling Methods and Protocols
This volume looks at the current advanced protocols used to study aspects of the B cell receptor (BCR). The chapters in this book cover topics such as the mutant of BCR repertoire to understand antibody evolution; interactions between B cells and viruses;
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Chaohong Liu Editor
B Cell Receptor Signaling Methods and Protocols
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
B Cell Receptor Signaling Methods and Protocols
Edited by
Chaohong Liu Department of Pathogen Biology, Huazhong University of Science and Technology, Huazhong, China
Editor Chaohong Liu Department of Pathogen Biology Huazhong University of Science and Technology Huazhong, China
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-7473-3 ISBN 978-1-4939-7474-0 (eBook) https://doi.org/10.1007/978-1-4939-7474-0 Library of Congress Control Number: 2017964500 © Springer Science+Business Media, LLC 2018 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer Science+Business Media, LLC The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface The B cell receptor (BCR) is critical for the function of B cells including cell survival, proliferation, and antibody secretion. It is a complex that is composed of two parts: a membrane-bound immunoglobulin molecule and a signal transduction moiety called Ig-α/Ig-β, bound together by disulfide bridges. When membrane-bound immunoglobulin interacts with an antigen, it induces receptor oligomerization and consequent signal transduction. Later the receptor goes through endocytosis for antigen processing and presentation to helper T cells. Therefore the BCR can transduce the antigen strength from outside into signal inside to maintain the normal function of B cells, and the defect in BCR signaling may cause different immune diseases such as immunodeficiency and
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