Wnt Signaling Methods and Protocols
Now poised to evaluate the potential in modulating Wnt signaling for therapeutic agendas in cancer, wound healing, and degenerative disease, this book collects protocols from an exciting area of study. The methodologies include using Wnt modulating chemic
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Quinn Barrett Lawrence Lum Editors
Wnt Signaling Methods and Protocols
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Wnt Signaling Methods and Protocols
Edited by
Quinn Barrett University of Texas Southwestern Medical Center, Dallas, TX, USA
Lawrence Lum Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA
Editors Quinn Barrett University of Texas Southwestern Medical Center Dallas, TX, USA
Lawrence Lum Department of Cell Biology University of Texas Southwestern Medical Center Dallas, TX, USA
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-6391-1 ISBN 978-1-4939-6393-5 (eBook) DOI 10.1007/978-1-4939-6393-5 Library of Congress Control Number: 2016942570 © Springer Science+Business Media New York 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer Science+Business Media LLC New York
Preface Secreted Wnt molecules are essential to the coordination of cell fate outcomes in developing and adult tissues and are thus indispensable to animal life. The past few decades of intense research have led to tremendous advances in the assembly of the genetic components necessary for the production of Wnt ligands and for eliciting cellular responses to Wnts. Having leveraged this knowledge to engineer the tools capable of achieving control of Wnt signaling in diverse adult animal tissues, we are now poised to evaluate the potential in modulating Wnt signaling for therapeutic agendas in cancer, wound healing, and degenerative disease. This collection of protocols should facilitate these efforts by providing step-by-step guidance for successfully evaluating researcher-inspired hypotheses. Included are methods fo
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