ErbB Receptor Signaling Methods and Protocols
This volume contains protocols specifically designed for studying cell signaling mediated by ErbB receptors, all applicable to the study of a broad range of ErbB receptor-mediated signaling from basic research to clinic applications, from cultured cells t
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Zhixiang Wang Editor
ErbB Receptor Signaling Methods and Protocols
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
ErbB Receptor Signaling Methods and Protocols
Edited by
Zhixiang Wang Department of Medical Genetics, University of Alberta, Edmonton, AB, Canada
Editor Zhixiang Wang Department of Medical Genetics University of Alberta Edmonton, AB, Canada
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-7218-0 ISBN 978-1-4939-7219-7 (eBook) DOI 10.1007/978-1-4939-7219-7 Library of Congress Control Number: 2017946170 © Springer Science+Business Media LLC 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer Science+Business Media LLC The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface There are more than 90 known protein tyrosine kinase genes in the human genome; 58 encode transmembrane protein receptor tyrosine kinases (RTKs) distributed into 20 subfamilies. Among them, the ErbB receptor family, also known as the EGF receptor family or type I receptor family, includes the epidermal growth factor (EGF) receptor (EGFR) or ErbB1/Her1, ErbB2/Her2, ErbB3/Her3, and ErbB4/Her4. Among all RTKs, EGFR was the first RTK identified and the first one linked to cancer. Thus, EGFR has also been the most intensively studied among all RTKs. ErbB receptors were first implicated in human cancer approximately three decades ago, when the avian erythroblastosis tumor virus was found to encode an aberrant form of the human epidermal growth factor (EGF) receptor (EGFR). Scientific communities have since developed
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