Bactericidal efficacy of electrospun pure and Fe-doped titania nanofibers
- PDF / 3,064,609 Bytes
- 10 Pages / 584.957 x 782.986 pts Page_size
- 71 Downloads / 250 Views
Saqib Ali The Ohio State University, Columbus, Ohio 43210-1173
Vijay Goel Departments of Bioengineering and Orthopedic Surgery, The University of Toledo, Toledo, Ohio 435606-3390 (Received 24 February 2010; accepted 20 April 2010)
This paper reports the development of nonwoven nanofibers of pure and iron-doped titanium dioxide (TiO2) and evaluation of their antimicrobial attributes for using them as disinfectant gauze for wound healing upon brief activation by ultraviolet/infrared (UV/IR) illumination. It was found that the fibers exhibited superior bactericidal affinity when exposed briefly (3–12 s) to either multiphoton laser or infrared radiations. On the other hand, exposure to a UV beam for up to 20 min was not effective in mitigating the bacterial colonization of the Escherichia coli.
I. INTRODUCTION
Tissue engineering has received extensive attention in recent years as an emerging and rapidly growing field. The ultimate goal of tissue engineering as a treatment concept is to replace or restore the anatomic structure and the function of damaged, injured, or missing tissue or organs following any injury or pathological process. This is facilitated by combining biomaterials, cells, tissue, biologically active molecules, and/or stimulating mechanical forces of the tissue microenvironment. The scaffolds ought to be hierarchical, porous structures to allow seeding of cells at high densities and, upon implantation into the body, to facilitate the infiltration and formation of large numbers of blood vessels for supplying nutrients to the transplanted cells and the removal of waste products. In this context, metal-containing nanoparticles (mostly quantum dots) have been exploited extensively. However, they still remain attractive merely as chemical, pharmacological, and medical toolboxes but not a clinical solution for diagnosis or therapy. Recent reviews have provided instructive examples of nanotechnology application in basic neurosciences and its use in addressing interesting biological questions.1–7 One of the most promising techniques of fabrication of biodegradable and/or physiologically benign and biosorbable scaffolds is electrospinning. Electrospun fibers are found to possess features that bear morphologic similarity to the extracellular matrix (ECM) of natural tissue, a)
Address all correspondence to this author. e-mail: [email protected] DOI: 10.1557/JMR.2010.0237 J. Mater. Res., Vol. 25, No. 9, Sep 2010
http://journals.cambridge.org
Downloaded: 13 Mar 2015
such as high porosity and effective mechanical properties. Because the natural scaffold consists of a multilayered fibrous and porous architecture, the possibility of using electrospinning as a novel nanomanufacturing technique applicable to tissue engineering makes sense. The technique of electrospinning uses external electrical forces to produce novel fibers of nearly uniform diameters in the range tens of nanometers and ranging in length from several micrometers to few millimeters. Potential application of this technology in the b
Data Loading...
