Beneficial Effects of Ibuprofen on Pentylenetetrazol-induced Convulsion
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ORIGINAL PAPER
Beneficial Effects of Ibuprofen on Pentylenetetrazol-induced Convulsion Ferit Durankuş1 · Evrim Şenkal1 · Eda Sünnetçi2 · Yakup Albayrak3 · Murat Beyazyüz3 · Özüm Atasoy4 · Oytun Erbaş5 Received: 15 May 2020 / Revised: 1 July 2020 / Accepted: 22 July 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) that is commonly used as an anti-inflammatory, anti-pyretic, and analgesic. Although some studies have focused on the anti-inflammatory and anti-pyretic properties of ibuprofen during febrile convulsions, only one has investigated its antiepileptic effects. In the present study, we aimed to investigate the effects of ibuprofen in rats exposed to pentylenetetrazol (PTZ)-induced seizures. In total, 48 rats were randomly divided in two groups: Group A for electroencephalography (EEG) recordings and Group B for behavioral assessment. All EEG recordings and behavioral assessment protocols were performed. In addition, groups were compared in terms of prostaglandin F2 alfa (PGF2α) levels in the brain. We demonstrated the beneficial effects of the administration of ibuprofen in PTZ-induced seizures in rats via the following findings: spike percentages and Racine convulsion scale values were significantly lower and first myoclonic jerk (FMJ) onset times were significantly higher in the ibuprofen-administered groups. Moreover, PGF2α levels in the brain were significantly higher in the saline and PTZ 70 mg/kg group than in the control and PTZ 70 mg/kg and 400 mg/kg ibuprofen groups. Our study is the first to demonstrate the beneficial effects of ibuprofen on seizures through behavioral, EEG, and PGF2α brain assessments. Ibuprofen can be used for epilepsy and febrile seizures safely and without inducing seizures. However, further experimental and clinical studies are needed to confirm our results. Keywords Epilepsy · Febrile · Seizure · Ibuprofen · Treatment
Introduction Epilepsy is one of the most common neurological diseases, affecting approximately 0.5–1% of the general population. It presents a serious health burden, and it has a mortality * Ferit Durankuş [email protected] 1
Department of Pediatrics, Istanbul Medeniyet University, Göztepe Eğitim ve Araştırma Hastanesi, Göztepe, İstanbul 34190, Turkey
2
Istanbul Training and Education Hospital, Department of Pediatrics, İstanbul, Turkey
3
Faculty of Medicine, Department of Psychiatry and Behavioural Neuroscience, Tekirdağ Namık Kemal University, Tekirdağ, Turkey
4
Department of Radiation Oncolgy, Kartal Education and Research Hospital, İstanbul, Turkey
5
Department of Physiology, Demiroğlu Bilim University Medical School, İstanbul, Turkey
rate of 2–3% in patients admitted to emergency services [1]. Epilepsy also commonly causes psychological, behavioral, and cognitive impairments; thus, impairment in functionality will be increased. Besides its high prevalence and effects on functionality, it can be said that effective control of seizures i
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