Ibuprofen
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Drug hypersensitivity reaction: 4 case reports In a study involving 215 patients who had undergone a drug provocation test (DPT) for suspected nonsteroidal anti-inflammatory drug (NSAID) hypersensitivity reaction between 1st January 2014 and 31st December 2018, four patients (three boys and one girl) aged 12.62-111.08 months were described who developed NSAID hypersensitivity reaction presenting as angioedema, urticaria or rash following treatment with ibuprofen as NSAID therapy [routes, dosages, time to reaction onsets not stated and outcomes not stated]. Patient 1: A 74.15-month-old boy developed NSAID hypersensitivity reaction presenting as facial angioedema and periorbital angioedema, following treatment with ibuprofen as NSAID therapy. The boy was receiving NSAID therapy with ibuprofen and subsequently developed facial angioedema. NSAID hypersensitivity was suspected and treatment with ibuprofen was discontinued. Five weeks after the development of facial angioedema, he underwent a DPT, which yielded negative result for ibuprofen. Therefore, he resumed treatment with ibuprofen. However, he developed periorbital angioedema which was also suspected to be a form of NSAID hypersensitivity reaction. Patient 2: A 12.62-month-old boy developed NSAID hypersensitivity reaction presenting as angioedema on the hands and rash, following treatment with ibuprofen as NSAID therapy. The boy was receiving NSAID therapy with ibuprofen and subsequently developed angioedema on the hands. NSAID hypersensitivity reaction was suspected and ibuprofen was discontinued. Thirteen months after the development of angioedema, he underwent a DPT, which yielded negative result for ibuprofen. Therefore, he resumed treatment with ibuprofen. However, he developed rash which was also suspected to be a form of NSAID hypersensitivity reaction. Patient 3: A 111.08-month-old girl developed NSAID hypersensitivity reaction presenting as urticaria, following treatment with ibuprofen as NSAID therapy. The girl was receiving NSAID therapy with ibuprofen and subsequently developed urticaria. NSAID hypersensitivity reaction was suspected and ibuprofen was discontinued. Five weeks after the development of urticaria, she underwent a DPT, which yielded negative result for ibuprofen. Therefore, she resumed treatment with ibuprofen. However, she developed urticaria which was also suspected to be a form of NSAID hypersensitivity reaction. Patient 4: A 104.87-month-old boy developed NSAID hypersensitivity reaction presenting as rash, following treatment with ibuprofen as NSAID therapy. The boy was receiving NSAID therapy with ibuprofen and subsequently developed rash. NSAID hypersensitivity reaction was suspected and ibuprofen was discontinued. Two years after the development of rash, he underwent DPT which yielded negative result for ibuprofen. Therefore, he resumed treatment with ibuprofen. However, he developed rash which was also suspected to be a form of NSAID hypersensitivity reaction. Topal OY, et al. Negative predictive value of provocation tests for
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