Bimetallic PtCu nanoparticles supported on molybdenum disulfide–functionalized graphitic carbon nitride for the detectio
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ORIGINAL PAPER
Bimetallic PtCu nanoparticles supported on molybdenum disulfide–functionalized graphitic carbon nitride for the detection of carcinoembryonic antigen Yiju Song 1 & Jingwen Qiao 1 & Wenjun Li 1 & Chaoyun Ma 1 & Siyu Chen 1 & Hongling Li 1 & Chenglin Hong 1 Received: 3 March 2020 / Accepted: 18 August 2020 # Springer-Verlag GmbH Austria, part of Springer Nature 2020
Abstract A molybdenum disulfide based graphite phase carbon nitride (MoS2/g-C3N4) which is supported by a platinum-copper nanoparticle (PtCu) Z-type catalyst was created in this study. The catalyst exploits optoelectronic synergistic effect with large surface area, good catalysis, and biocompatibility to amplify the signal. The electrode impedance of the synthesized MoS2/g-C3N4-PtCu was reduced five times in visible light compared with dark conditions, thereby improving the detection of carcinoembryonic antigen (CEA). At a voltage of − 0.4 V, the immunoprobe constructed with this material is used for CEA detection. A linear relationship between 100 fg mL−1 and 80 ng mL−1 concentrations was achieved with a minimum detection limit of 33 fg mL−1 (S/N = 3). The recovery rate was 103–104%, and the relative standard deviation was 2.9–3.8%. This implies that the sandwich immunosensors have good reproducibility, selectivity, and stability and can be used in various applications. Keywords MoS2/g-C3N4-PtCu . Z-type catalyst . Carcinoembryonic antigen
Introduction Carcinoembryonic antigen (CEA) provides an important basis for early diagnosis and treatment of colorectal cancer [1], lung cancer [2], breast cancer [3], and pancreatic cancer [4] and is often used as a marker for cancer embryonic antigen. The methods commonly used for CEA detection include electrochemiluminescence immunosensor [5], fluorescent labeling [6, 7], enzyme-linked immunosorbent assay [8], and photoelectrochemical immunoassay [9]. Although, there are some setbacks such as high cost, the complexity of instrument used, and long time consumption in the effectiveness of these methods mentioned above [10], whereas the advantages of Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00604-020-04498-y) contains supplementary material, which is available to authorized users. * Hongling Li [email protected] * Chenglin Hong [email protected] 1
Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan, School of Chemistry and Chemical Engineering, Shihezi University, Shihezi 832003, China
electrochemical immunosensors are its high sensitivity, low cost, simple equipment, and fast analysis [11]. In particular, sandwich-type sensors that exploit the high specificity between antigens and antibodies have become popular research areas [12]. Graphitized carbon nitride (g-C3N4), a non-metallic polymer catalyst with a bandgap of about 2.7 eV, has attracted the attention of researchers greatly [13]. It has well visible-light absorption, low toxicity, and stable bonding of carbon and nitrogen atoms, and the layers are bonded w
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