Bio-Engineered Copper Oxide Nanoparticles Using Citrus Aurantifolia Enzyme Extract and its Anticancer Activity
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ORIGINAL PAPER
Bio-Engineered Copper Oxide Nanoparticles Using Citrus Aurantifolia Enzyme Extract and its Anticancer Activity Jacob Vincent1,2 • N. Chandra Lekha1 Received: 8 August 2020 / Accepted: 3 November 2020 Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Copper oxide (CuO) NPs offer promising applications and green synthesis is widely preferred over synthetic methods because of its merits. The past literatures show the preparation of copper nanoparticles from plants extract of leaves but not from the enzymes. But here the greener method of CuO nanoparticles which has been derived from enzymes extract of Citrus aurantifolia is reported. When the enzyme powder obtained from leaf extracts of Citrus aurantifolia was treated with copper sulphate, copper oxide nanoparticles were produced. Such nanoparticles prepared are characterized by UV– Vis, FT-IR, XRD, HR-TEM and scanning electron microscope studies. On the other hand, antibacterial activity against K. pneumonia and S. aureus, was evaluated. Results showed sensibility of K. pneumonia and S. aureus and the antibacterial property improves infections due to drug-resistant bacteria’s. Keywords Citrus aurantifolia Copper nanoparticles Klebsiella pneumoniae Staphylococcus aureus and cancer activities
Introduction These days, microbes are skilled to coordinate to hassled circumstance as well as figure varied instrument of barrier since of enormous exploitation of anti-microbials, which prompt a reflective concern in therapeutic troubles [1]. The most widely recognized risky multidrug-safe pathogens are Acineto bacter baumannii, E.coli, penicillin-safe Streptococcus pneumoniae, Klebsiella pneumoniae, vancomycinsafe Enterococcus, methicillin-safe S. aureus, and broadly medicate safe Mycobacterium tuberculosis [2]. In this way, consideration is attracted to treatment rules and the utilization of novel antimicrobial operators with better bactericidal properties [3].The unavoidable task in the applied science is the communication of living molecules and the inorganic precursors [4]. In this circumstance, nanotechnology has concentrated on the improvement of nanomaterials with the capacity to communicate with organic & Jacob Vincent [email protected] 1
Department of Chemistry, Kamaraj College, Thoothukudi 628003, TamilNadu, India
2
Manonmaniam Sundaranar University, Abishekapatti, Tirunelveli 627012, TamilNadu, India
elements that are pathogenic to people. In future, nanostructure engineering will be involved to judiciously design and optimize the performance [5]. In chemical reactions, the primary steps towards greener approach are the use of non-toxic and non-volatile solvent as well as conservation of energy without debris [6]. Hence, the replacement of organic solvents by phytochemicals present in plants is an important step in green chemistry. Among these, preparation of metal nanoparticles has pulled in logical intrigue, in view of the bactericidal properties appeared by
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