Bioactive Wound Dressing Gauze Loaded with Silver Nanoparticles Mediated by Acacia Gum
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ORIGINAL PAPER
Bioactive Wound Dressing Gauze Loaded with Silver Nanoparticles Mediated by Acacia Gum Mehrez E. El-Naggar1 • Abdelrahman M. Abdelgawad1,3 • Dalia A. Elsherbiny2,3 • Waffa A. El-shazly2 Samaneh Ghazanfari3 • Mohamed S. Abdel-Aziz4 • Yasser K. Abd-Elmoneam2
•
Received: 16 November 2019 Ó Springer Science+Business Media, LLC, part of Springer Nature 2019
Abstract A wound dressing is very crucial component in wound healing process. Bioactive dressings play important role in wound sterilization and promote tissue healing and growth. The present work investigated the preparation of AgNPs in solid-state using acacia gum as both reductant and stabilizing agent. Sodium hydroxide (NaOH) was employed as activating agent and pH mediator. Acacia is a naturally occurring mixture of polysaccharides and glycoproteins. The obtained particles were in the range of 50 nm. The work was extended to evaluate the antimicrobial of AgNPs treated gauze cotton fabrics against gram positive (S. aureus), gram negative (P. aeruginosa) bacteria, C. albicans (yeast); and A. Niger (fungus). The inhibition zone of the as prepared silver nanoparticles was found to be 24 mm against both types of bacteria, 23 mm against C. albicans (yeast), and inactive against A. Niger (fungus). On the other hand, the treated gauze showed bactericidal behavior and a clear zone was found underneath the samples on the agar plate. The reduction percent in number of bacterial colonies of treated gauze fabrics in comparison to control Pseudomonas aeruginosa culture showed a reduction up to 100%. The aforementioned results promote the acquirement of bioactive antibacterial wound dressing. Keywords Acacia gum Silver nanoparticles Solid state Gauze fabric Wound dressing
Introduction Nanotechnology provides new potentials to fight and prevent disease using small and/or atomic sized materials. Metallic nanoparticles show unique chemical activity. This might be attributed to their enormous surface to volume ratios and crystallographic surface [1]. Nanomaterials is & Mehrez E. El-Naggar [email protected]; [email protected] & Abdelrahman M. Abdelgawad [email protected] 1
Textile Research Division, National Research Centre, Dokki, Cairo, Egypt
2
Chemistry Department, Faculty of Science, Menoufia University, Shebin El-Koom, Menoufia, Egypt
3
Aachen-Maastricht Institute for Biobased Materials, Faculty of Science and Engineering, Maastricht University, Maastricht, The Netherlands
4
Genetic Engineering and Biotechnology Division, National Research Center, Dokki, Cairo, Egypt
considered as a part from nanotechnology science that have active surface area, and very small size [2]. These mentioned parameters encourage the application of nanomaterials in many different applications such as pharmaceutical applications such as anti-cancer, anti-parasite, bactericidal and fungicidal, etc. [3–6]. Among all the candidates applied for the treatment of infections with bacteria, silver nanoparticles (AgNPs)
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