C-Type Lectin Receptors in Phagocytosis
C-type lectin receptors (CLRs) are a family of transmembrane proteins having at least one C-type lectin-like domain (CTLD) on the cell surface and either a short intracellular signaling tail or a transmembrane domain that facilitates interaction with a se
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Introduction.......................................................................................................................... Mechanisms of Phagocytosis .............................................................................................. C-Type Lectin Receptors..................................................................................................... 3.1 Dectin-1 ...................................................................................................................... 3.2 Dectin-2 ...................................................................................................................... 3.3 Mincle and MCL ........................................................................................................ 3.4 DC-SIGN and DC-SIGNR ......................................................................................... 3.5 LSECtin ...................................................................................................................... 3.6 Lox-1........................................................................................................................... 3.7 DNGR-1...................................................................................................................... 4 Additional Phagocytosis-Linked C-Type Lectin Domain-Containing Proteins ................. 4.1 The Mannose Receptor............................................................................................... 4.2 Collectins .................................................................................................................... 5 Conclusion ........................................................................................................................... References ..................................................................................................................................
Abstract C-type lectin receptors (CLRs) are a family of transmembrane proteins having at least one C-type lectin-like domain (CTLD) on the cell surface and either a short intracellular signaling tail or a transmembrane domain that facilitates interaction with a second protein, often the Fc receptor common gamma chain (FcRc), that mediates signaling. Many CLRs directly recognize microbial cell walls K. Li D. M. Underhill (&) F. Widjaja Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA e-mail: [email protected] K. Li D. M. Underhill Division of Immunology, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA Current Topics in Microbiology and Immunology https://doi.org/10.1007/82_2020_198 © Springer Nature Switzerland AG 2020
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K. Li and D. M. Underhill
and influence innate immunity by activating inflammatory and antimicrobial responses in phagocytes. In this review, we examine the contributions of certain CLRs to activation and regulation of phagocytosis in cells such as macrophages, dendritic cells and neutrophils.
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