Cartographic Analysis of Random Inbreeding and Surname Structure of the Population of North Ossetia
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Cartographic Analysis of Random Inbreeding and Surname Structure of the Population of North Ossetia G. I. El’chinovaa, *, V. V. Kadysheva, Z. K. Getoevab, M. Yu. Dzhadzhievab, A. B. Vekshinaa, Yu. A. Revazovac, A. O. Lepeshinskayaa, and R. A. Zinchenkoa, d aResearch
Centre for Medical Genetics, Moscow, 115522 Russia Republican Children’s Clinical Hospital, Vladikavkaz, 362003 Russia c Erisman Federal Scientific Center of Hygiene, Moscow oblast, Mytishchi, 141000 Russia d N.A. Semashko National Research Institute of Public Health, Moscow, 105064 Russia *e-mail: [email protected] b
Received August 1, 2019; revised October 3, 2019; accepted October 16, 2019
Abstract—A cartographic analysis of the values of random inbreeding obtained by the isonymy method, as well as the Barrai parameters considered as an extension of the isonymy method, was carried out. In North Ossetia, two opposite extremes with different degrees of expressiveness—in the Mozdoksky and Irafsky districts—were revealed. Keywords: cartographic analysis, isonymy method, North Ossetia, random inbreeding, Barrai parameters DOI: 10.1134/S1022795420080037
For almost four decades, the staff of the Laboratory of Genetic Epidemiology of the Research Centre for Medical Genetics has been conducting complex genetic and epidemiological studies of the Russian population. During this time, Kostroma, Kirov, Arkhangelsk, Bryansk, Tver, and Rostov oblasts, Krasnodar krai, and the Republics of Adygea, Chuvashia, Udmurtia, Mari El, Bashkiria, Tatarstan, and Karachay-Cherkessia were examined. Research results are widely presented in the publicly available sources. A study is currently under way in the Republic of North Ossetia-Alania. All work is carried out in accordance with the developed protocol [1]. The protocol includes (1) repeated visits by a team of geneticists to the region under study to examine patients with an alleged hereditary pathology and to take blood samples for molecular genetic confirmation of the diagnosis; (2) collection of population genetic and demographic genetic information of both biological and nonbiological nature from as many sources as possible; (3) statistical processing of available data, including segregation analysis. One of the most important parameters of the population genetic structure is the value of random inbreeding. Its influence on the prevalence of hereditary pathology has been confirmed by a number of domestic and foreign researchers. Wright’s random inbreeding [2] is calculated as one-fourth of the sum of the squares of surname frequencies. The surname has long been successfully used as a population genetic marker by both domestic
and foreign authors. As an extension of the isonymic method, the Barrai parameters are used [3].
2 Random isonymy calculated as Ir = qi , where qi is the frequency of the ith surname in the population. On the basis of Ir, random inbreeding can be deter-
2 mined Fst = Ir/ 4 = qi 4. The migration index is calculated as v = (1 – Ir)/[Ir(N – 1)], where N is the number of
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