Chemical composition, in vitro antioxidant, and enzymes inhibitory potential of three medicinally important plants from
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RESEARCH ARTICLE
Chemical composition, in vitro antioxidant, and enzymes inhibitory potential of three medicinally important plants from Nepal (Lepisorus mehrae, Pleurospermum benthamii, and Roscoea auriculata) Bishnu Prasad Pandey1 · Suman Prakash Pradhan1 Received: 20 August 2020 / Accepted: 9 November 2020 © Institute of Korean Medicine, Kyung Hee University 2020
Abstract The aim of this study was to examine antioxidant properties, major enzyme inhibition activities, and targeted metabolites profiling of Lepisorus mehrae, Pleurospermum benthamii, and Roscoea auriculata in different solvent extracts. This is the first report on metabolites profiling and biochemical activities of these plant species. Our results revealed that L. mehrae, P. benthamii, and R. auriculata are rich source of bioactive secondary metabolites and have good antioxidant potential. The methanol extract of L. mehrae, P. benthamii, and R. auriculata showed substantial inhibitory potential towards elastase, whereas water extract of L. mehrae and R. auriculata were more strong inhibitors of tyrosinase. Among the three plants, P. benthamii showed noteworthy inhibition on α-amylase, α-glucosidase, lipase, tyrosinase, elastase, and cholinesterases enzymes. High resolution mass spectrometry analysis revealed the presence of metabolites such as Protocatechuic acid, Gallic acid, 7,8,3′,4′-tetrahydroxyflavanone, Rhamnocitrin, Quercetin, Hyperoside, Quercetin-7-glucoside, Rutin, Rhamnetin, Aromadendrin, Camphor, and Hexanoic acid in L. mehrae. Moreover, Catechin and Fisetin were present in P. benthamii and Kaempferide, 7,8,3′,4′-Tetrahydroxyflavone, 5,7-Dihydroxy-2,3-dihydroflavonol 3-acetate, and Aromadendrin were present in R. auriculata. The results presented here provide enough scientific evidence that these plant species have diverse biochemical potential and can be examined further for their potential use in modern pharmaceuticals, cosmetics, and nutraceuticals.
* Bishnu Prasad Pandey [email protected] 1
Department of Chemical Science and Engineering, Kathmandu University, PO Box No. 6250, Dhulikhel, Kavre, Nepal
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B. P. Pandey, S. P. Pradhan
Graphic abstract
Keywords Lepisorus mehrae · Pleurospermum benthamii · Roscoea auriculata · Enzymes inhibition · Antioxidant · Metabolites
Introduction The overconsumption of fats and glucose had an adverse effect on the person suffering from obesity and diabetes. The World Health Organization (WHO) defines obesity as abnormal fat accumulation leading to health risks such as diabetes, cardiovascular diseases, and cancer (Marrelli et al. 2018). International diabetes federation has reported 463 million cases worldwide, among them, 88 million are in the South Asian population, and world diabetes cases are projected to reach around 642 million by 2040 (IDF 2015). Despite of significant progress in modern synthetic drugs, the vast majority of the world population still relies on medicinal plants and herbs as a means of complementary and alternative medicine (Elbashir et al.
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