Circular RNAs Methods and Protocols

This volume provides established approaches for identifying, characterizing, and manipulating circRNAs in vitro, in vivo, and in silico.  Chapters highlight the breakthroughs and the challenges in this new field of research. Written in the highly suc

  • PDF / 8,242,944 Bytes
  • 223 Pages / 504.63 x 737.01 pts Page_size
  • 37 Downloads / 254 Views

DOWNLOAD

REPORT


Christoph Dieterich Argyris Papantonis Editors

Circular RNAs Methods and Protocols

Methods

in

Molecular Biology

Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK

For further volumes: http://www.springer.com/series/7651

Circular RNAs Methods and Protocols

Edited by

Christoph Dieterich Department of Internal Medicine III, Klaus Tschira Institute for Integrative Computational Cardiology, University Hospital Heidelberg, Heidelberg, Germany

Argyris Papantonis Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany

Editors Christoph Dieterich Department of Internal Medicine III Klaus Tschira Institute for Integrative Computational Cardiology University Hospital Heidelberg Heidelberg, Germany

Argyris Papantonis Center for Molecular Medicine Cologne (CMMC) University of Cologne Cologne, Germany

ISSN 1064-3745     ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-7561-7    ISBN 978-1-4939-7562-4 (eBook) https://doi.org/10.1007/978-1-4939-7562-4 Library of Congress Control Number: 2017962947 © Springer Science+Business Media, LLC 2018 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer Science+Business Media, LLC The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.

Preface Although isolated examples of circularized RNA molecules were already described more than 20 years ago [1, 2], it was not until quite recently that the prevalence of circular RNAs (circRNAs) was revealed. The advent of massively parallel sequencing technology allowed researchers to catalogue circRNAs across eukaryotic and prokaryotic systems (e.g., [3–7]). Their surprisingly high titers within cells are a resul