Circulating microRNAs in Disease Diagnostics and their Potential Biological Relevance
MicroRNAs as the endogenous mediators of RNA interference have experienced an unprecedented career in recent years, highlighting their pathogenic, diagnostic and potential therapeutic relevance. Beside tissue microRNAs, they are also found in body fluids,
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Peter Igaz Editor
Circulating microRNAs in Disease Diagnostics and their Potential Biological Relevance
Experientia Supplementum
Volume 106
More information about this series at http://www.springer.com/series/4822
Peter Igaz Editor
Circulating microRNAs in Disease Diagnostics and their Potential Biological Relevance
Editor Peter Igaz 2nd Department of Medicine Semmelweis University Budapest, Hungary
ISSN 1023-294X Experientia Supplementum ISBN 978-3-0348-0953-5 ISBN 978-3-0348-0955-9 DOI 10.1007/978-3-0348-0955-9
(eBook)
Library of Congress Control Number: 2015957587 Springer Basel Heidelberg New York Dordrecht London © Springer International Publishing Switzerland 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Springer Basel AG is part of Springer Science+Business Media (www.springer.com)
Preface
The discovery of RNA interference and their endogenous mediators, microRNAs, has revolutionized molecular biology in the past two decades. Beside their obvious biological relevance, microRNAs can also be exploited as biomarkers and even as potential therapeutic targets. One of the most recent developments of microRNA research was the recognition of secreted microRNA that can be detected in body fluids, most importantly in the blood. Circulating bloodborne microRNAs might represent a novel, minimally invasive diagnostic tool that might be exploited in many diseases. However, there are major technical difficulties to be conquered, and standardization of analytical methods is needed for their successful clinical introduction. The biological relevance of circulating microRNAs is intriguing as this might represent a form of paracrine or even endocrine (hormonal) communication that would convey epigenetic information to cells or tissues distant from the microRNA-secreting source. This book focuses on this fascinating and rapidly developing research field. Both researchers and students of biology or medicine could find this topic interesti
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