Biogenic Silver Nanoparticles: Evaluation of Their Biological and Catalytic Potential
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ORIGINAL RESEARCH ARTICLE
Biogenic Silver Nanoparticles: Evaluation of Their Biological and Catalytic Potential Bhawna Sharma1,4 • Indu Singh2,3 • Somvir Bajar4 • Seema Gupta3 Hemant Gautam2 • Pradeep Kumar1
•
Received: 12 February 2020 / Accepted: 20 May 2020 Ó Association of Microbiologists of India 2020
Abstract The biogenic tailoring of silver nanoparticles using plant extract is becoming an attractive approach in the current scenario. Manilkara zapota (MZ) is well known for its antibacterial, hepato-protective, anti-inflammatory, anti-tussive, anti-fungal, anti-tumour, and free radical scavenging potential. Its plants extract is a rich source of secondary metabolites. Nowadays, silver nanoparticles (AgNPs) have been advocated for a variety of biomedical applications. In present work, silver nanoparticles have
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s12088-020-00889-0) contains supplementary material, which is available to authorized users. & Pradeep Kumar [email protected] Bhawna Sharma [email protected] Indu Singh [email protected] Somvir Bajar [email protected] Seema Gupta [email protected] Hemant Gautam [email protected] 1
CSIR-Institute of Genomics and Integrative Biology, North Campus, Mall Road, Delhi, Delhi 110007, India
2
CSIR-Institute of Genomics and Integrative Biology, South Campus, Mathura Road, New Delhi, Delhi 110020, India
3
Acharya Narendra Dev College, University of Delhi, Govindpuri, Kalkaji, New Delhi 110019, India
4
Department of Environmental Sciences, J.C. Bose University of Science and Technology, YMCA, Faridabad, Haryana 121006, India
been synthesized using an aqueous extract of MZ, physicochemically characterized and finally evaluated for antimicrobial effects, catalytic reduction/degradation of organic dyes and cytotoxicity. The nanosized AgNPs (* 84 nm) were found to possess prominent antibacterial potential against gram positive and gram negative pathogens (MIC 50 lg/ml) in comparison to native plant extract. Moreover, these particles were found to be non-toxic and efficient eradicators of environmental toxicants via rapid catalytic reduction of toxic chemicals and dyes. Altogether, these results suggest promising potential of these nanoparticles that can be used as multifunctional agents for future biomedical applications. Keywords Manilkara zapota Phytonanotechnology Silver nanoparticles Catalytic reduction Antibacterial Antibiofilm Antioxidant activity
Introduction Recently, metal-based nanoparticles have been shown to possess promising potential in biomedical applications. The conversion of bulk material into nano-sized particles results in the exhibition of unique properties of matter owing to significantly increased surface area to volume ratio [1, 1 of mss]. Because of these unique properties, nanoparticles have been inculcated in the biosensor, nanocatalyst, antimicrobial, pharmaceutical, and environmental applications [2–6]. These properties have also made them active again
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