Clinical Applications of Mass Spectrometry in Drug Analysis Methods

This volume describes methods and protocols for a number of drugs and toxins in a stepwise manner. Chapters in the book cover a wide array of topics such as: quantitation of Flecainide, Mexiletine, Propafenone, and Amiodarone in Serum or Plasma; quantitat

  • PDF / 8,118,231 Bytes
  • 273 Pages / 504.63 x 737.01 pts Page_size
  • 97 Downloads / 193 Views

DOWNLOAD

REPORT


Uttam Garg Editor

Clinical Applications of Mass Spectrometry in Drug Analysis Methods and Protocols

METHODS

IN

MOLECULAR BIOLOGY

Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK

For further volumes: http://www.springer.com/series/7651

Clinical Applications of Mass Spectrometry in Drug Analysis Methods and Protocols

Edited by

Uttam Garg Department of Pathology & Lab Medicine, Children’s Mercy Hospitals & Clinics, Kansas City, MO, USA

Editor Uttam Garg Department of Pathology & Lab Medicine Children’s Mercy Hospitals & Clinics Kansas City, MO, USA

ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-3251-1 ISBN 978-1-4939-3252-8 (eBook) DOI 10.1007/978-1-4939-3252-8 Library of Congress Control Number: 2015956617 Springer New York Heidelberg Dordrecht London © Springer Science+Business Media New York 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Humana Press is a brand of Springer Springer Science+Business Media LLC New York is part of Springer Science+Business Media (www.springer.com)

Dedication This book is dedicated to my wife Jyotsna and daughters Megha and Mohini who are my inspiration to keep moving forward in life.

Preface Applications of mass spectrometry particularly in the fields of drugs and toxins analyses are growing exponentially. This is due to the facts that the newer instruments are much more user-friendly, less expensive, compact, and robust. Furthermore, the technology is versatile and generally does not require any special reagents such as antibodies to the drugs. Other advantages of mass spectrometry include increased sensitivity and specificity and multicomponent analysis. Using this technology hundreds to thousands of compounds can be screened in a single assay run. This volume Clinical Applications of Mass Spectrometry in Drug Analysis provides methods and protocols for a number of drugs