Characteristics of recovered COVID-19 patients with recurrent positive RT-PCR findings in Wuhan, China: a retrospective
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RESEARCH ARTICLE
Open Access
Characteristics of recovered COVID-19 patients with recurrent positive RT-PCR findings in Wuhan, China: a retrospective study Tie-Jun Shui1†, Chao Li2†, Hong-bing Liu3, Xiaohua Chen4,5*
and Bi-ke Zhang6*
Abstract Background: Two months after the outbreak of coronavirus disease 2019 (COVID-19) in Wuhan, China, tens of thousands of hospitalized patients had recovered, and little is known about the follow-up of the recovered patients. Methods: The clinical characteristics, reverse transcriptase-polymerase chain reaction (RT-PCR) results from throat swab specimens and the results of serological COVID-19 rapid diagnostic test (RDT) for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were retrospectively reviewed for a total of 758 recovered patients who were previously hospitalized in 17 hospitals and quarantined at 32 rehabilitation stations in Wuhan, China. Results: In total, 59 patients (7.78%) had recurrent positive findings for COVID-19 on RT-PCR from throat swabs. With regard to antibody detection, 50/59 (84.75%) and 4/59 (6.78%) patients had positive IgG or dual positive IgG/ IgM RDT results, respectively. Conclusions: Some patients who had been quarantined and had subsequently recovered from COVID-19 had recurrent positive RT-PCR results for SARS-CoV-2, and the possibility of transmission of the virus by recovered patients needs further investigation. Trial registration: Current Controlled Trials ChiCTR2000033580, Jun 6th 2020. Retrospectively registered. Keywords: SARS-CoV-2, COVID-19, Recurrent, RT-PCR
Background Coronavirus disease 2019 (COVID-19) is an emerging infectious respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that first emerged in early December 2019 in Wuhan, China. As of March 15, COVID-19 had affected 81,062 individuals in
* Correspondence: [email protected]; [email protected] † Tie-Jun Shui and Chao Li contributed equally to this work. 4 Beijing Tropical Medicine Research Institute, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China 6 Chinese Center for Disease Control and Prevention, Beijing 102206, China Full list of author information is available at the end of the article
China, and 67,041 had recovered after the application of multiple aggressive treatments. According to the national recommendations for the diagnosis and treatment of pneumonia caused by SARSCoV-2 (5th edition) and the current status of clinical practice in Hubei Province, real-time reverse transcriptase–polymerase chain reaction (RT-PCR) was used to detect SARS-CoV-2 in respiratory secretions [1, 2]. The patients suspected of having COVID-19 were diagnosed by positive RT-PCR for SARS-CoV-2, and 2 consecutively negative RT-PCR results were used as a criterion for hospital discharge. Then, the patients who had recovered from COVID-19 were quarantined at the
© The Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, shari
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