Clostridium difficile
Clostridium difficile has been recognized as the cause of a broad spectrum of enteric disease ranging from mild antibiotic-associated diarrhea to pseudomembranous colitis. This volume gives new insights into the microbiology, diagnostics and epidemiology
- PDF / 15,053,227 Bytes
- 148 Pages / 438.958 x 668.938 pts Page_size
- 0 Downloads / 217 Views
Editors R.W. Compans, Atlanta/Georgia M . Cooper, Birmingham/Alabama · Y. Ito, Kyoto H. Koprowski, Philadelphia/ Pennsylvania· F. Melchers, Basel M . Oldstone, La Jolla /California · S. Olsnes, Oslo M. Potter, Bethesda/ Maryland P.K. vogt , La Jolla /California · H . Wagner, Munich
Springer-Verlag Berlin Heidelberg GmbH
Clostridium difficile Edited by K. Aktories and T.D. Wilkins
With 20 Figures and II Tables
Springer
Prorcssor Or.Dr. KLAlJS AKTOR IF.S AI berl-l ud wigs- U n vcrsihl i t F rciburg. Instilut fUr Pharm:Jko logic ulld Toxikologic Hcrmann-Hcnlcr-Str. 5 79 104 Freiburg i.Br. Gcrmany E-lIIai/: aklOrics(/I' uni-rrciburg.dc
Or. T"'A('Y D. WILKINS Directo r o r Bi olL"Chnology Virginia Tech Frd lin Biotcchno logy Ccnler Wcst Campus Drivc. MC 0346 Blacksb urg. VA 24061
USA
E-mail: tracyw(II'YI,edu
("m'f'r I lIu.I'rralioll: 8io(lsy x(lf'n'm('11 from
1/
JlIIIÎ('1II 1\'ÎIII I'.I'('U(/II-
II/C'lIIhrcmOlI.I· ('olili.l' il1lhu'('(1 hy C loslridiurn diflicilc. Font! .1'lIlw/'ficÎ(/II/('(·ro.~i.\·
oI rll" ('olollÎ(' lII/lnl.l·a
l1'illl a 1.1'(1;('(// IIII1Sllrolllll-/ikt'
d('Spo.l'iriulI I!f.lih/'ill l1'ilh fi .1('11' xrallld(l( ·,I'If'.~, ICr!/l/'If'.\Y I!! Pr/!f Dr. 1'.".-11, Sd,of'{c-r. PUflm/ogi.w·/If'.I' 1II.I'Iil/li ( LI/dll'ig-A.I·('lw": l/a/l.I') ti!'/' Ullil'f'r.r;Iri'1 Frl'ihu/'x. Gf'rIIlllllyJ
ISSN 0070-21 7X ISBN 978-3-642-08668-7 ISBN 978-3-662-06272-2 (eBook) DOI 10.1007/978-3-662-06272-2 This work i•• ,,1>;''''1 1" ~"I'yrillhl, AII rillht, arc f\:",n'l.~1. Wh,·Ih..'r 11o~ ... h,,1Îon r.. r U,", n'II.,1 "1",,)"' ..... "l>lain,'Il 1'",,,, Spi,..,...vorlq, Balin HcidclbaJ OmbH,
or
"r
VioIali"ns a'" lial>le ror I'""""uli"" ul1tilhad by SPrinea-·V~ Bcrli:n Hcidclbat New York in 1000 Sofk:o,u- rqriD1 aflbt _
Libr~ry
of ('.. n~ ....",-,
... 1. _
( 'al~IOţ
1000
("ard Numl>...,- 15-1 ~~IU
The usnu"li"" a h"ul dos;Jgc "nd application l l'i"illll/ "ifflelle to xin s Property
Toxin A
Toxin B
Mr Pi Cytotoxicity" Lethal dose" Enterotoxicity'
:lOX.OOU 5.6 lOng 'iOng Ipg
270.000 -1 .2
HemagglutinationL'
G lucosy ltra sfe rase " Minimulll dose causing > 50 ' X,rounding or CIiO-K I cdl s. "Minimulll lethal dose ror intraperitoneal challenge or mice. ' Minimum dose causing Iluid secretion in rabhit il ea l loop assay. d Toxin B rrom variant strain SS64 is cntcrot ox ic. 'Agglutinati on o r rabbit erythrocytes at 4°C.
I pg SOil!.! d
-
Genetics of nos/ridil/III di/ficil" Toxins
37
toxin B, is a potent cytotoxin for epithelial cells of intestinal origin such as HT-29 cells (TUCKER et al. 1990). These cells have a high density of carbohydrate receptors for toxin A. Rounding of intoxicated cells is accompanied by disassembly of the actin micro filaments. Microtubules and intermediate filaments are only secondarily affected (FIORENTINI et al. 1990; MITCHELL et al. 1987; OTTLINGER and LIN 1988; THELESTAM and BRONNEGARD et al. 1980). Although the microfilament cytoskeleton is preferentially affected, actin itself is not the target. Rearrangement of actin and the aetin binding proteins vi
Data Loading...
