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Ebrahim Ghafar-Zadeh Mohamad Sawan

ACSP Analog Circuits And Signal Processing

CMOS Capacitive Sensors for Lab-on-Chip Applications A Multidisciplinary Approach

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CMOS Capacitive Sensors for Lab-on-Chip Applications

Analog Circuits and Signal Processing

For other titles published in this series, go to www.springer.com/series/7381

Ebrahim Ghafar-Zadeh    Mohamad Sawan ●

CMOS Capacitive Sensors for Lab-on-Chip Applications A Multidisciplinary Approach

Ebrahim Ghafar-Zadeh Department of Electrical Engineering Ecole Polytechnique de Montréal Montreal QC Canada [email protected]

Mohamad Sawan Department of Electrical Engineering Ecole Polytechnique de Montréal Montreal QC Canada [email protected]

ISBN 978-90-481-3726-8 e-ISBN 978-90-481-3727-5 DOI 10.1007/978-90-481-3727-5 Springer Dordrecht Heidelberg London New York Library of Congress Control Number: 2010921594 © Springer Science+Business Media B.V. 2010 No part of this work may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording or otherwise, without written permission from the Publisher, with the exception of any material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)

Contents

1 Introduction................................................................................................ 1.1 Overview of Lab-on-Chip................................................................... 1.1.1 Main Objectives of LoC Systems........................................... 1.2 From Macro to Micro Bioassays......................................................... 1.2.1 Micro-scale Liquid Handling.................................................. 1.2.2 Thermal Management in Microenvironment.......................... 1.2.3 DNA Amplification................................................................. 1.2.4 Sample Handling..................................................................... 1.2.5 Advantages of Performing Bioassays in Microscale.............. 1.3 CMOS-Based LoC.............................................................................. 1.3.1 Manipulation Methods............................................................ 1.3.2 Optical Techniques.................................................................. 1.3.3 Electrochemical Sensors......................................................... 1.3.4 Mechanical Sensors................................................................ 1.3.5 Magnetic Sensor...................................................................... 1.3.6 Temperature Control............................................................... 1.3.7 Capacitive Sensing LoC.......................................................... 1.4 Objectives and Organization of Book.................................................

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