Cocaine use as an independent predictor of cardiac steatosis: initial experience by 1H spectroscopy
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BioMed Central
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Oral presentation
Cocaine use as an independent predictor of cardiac steatosis: initial experience by 1H spectroscopy Chia-Ying Liu*1, Alban Redheuil1, Ronald Ouwerkerk2, Joao Lima1, David Bluemke3 and Shenghan Lai4 Address: 1The Johns Hopkins Hospital, Baltimore, MD, USA, 2The National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, USA, 3Radiology and Imaging Sciences, National Institutes of Health, NIH, Bethesda, Bethesda, MD, USA and 4Department of Epidemiology, Johns Hopkins School of Hygiene and Public health, Baltimore, MD, USA * Corresponding author
from 13th Annual SCMR Scientific Sessions Phoenix, AZ, USA. 21-24 January 2010 Published: 21 January 2010 Journal of Cardiovascular Magnetic Resonance 2010, 12(Suppl 1):O90
doi:10.1186/1532-429X-12-S1-O90
Abstracts of the 13th Annual SCMR Scientific Sessions - 2010
Meeting abstracts - A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/files/pdf/1532-429X-11-S1-infoThis abstract is available from: http://jcmr-online.com/content/12/S1/O90 © 2010 Liu et al; licensee BioMed Central Ltd.
Introduction Elevated myocardial triglyceride levels have been observed within the myocardium of diabetic and obese individuals. Use of cocaine leads to cardiomyopathy and precipitation of cardiovascular disease such as myocardial infarction, ventricular arrhythmias, and left ventricular dysfunction. Proton magnetic resonance spectroscopy (1H-MRS) has been applied to measure lipid overload in the human heart [1].
Fat content was quantified with Amares/MRUI and related to water in unsuppressed spectra and expressed as fat/ water percent ratios.
Results
The primary goal of the present study was to evaluate the myocardial fat in cocaine abusers. We applied 1H-MRS to quantify myocardial septal triglyceride content compared to the non-cocaine users to ascertain the prevalence and severity of cardiac steatosis among cocaine-use patients.
The characteristics of study participants are presented in Table 1. Using a 1% cut-off for cardiac steatosis, the overall prevalence of cardiac steatosis was 32% (14/44). The prevalence of cardiac steatosis in cocaine users was significantly higher than that in those who did not use cocaine (65.7% in cocaine users, and 16.7% in cocaine non-users, p < 0.004). Exact logistic regression analysis indicated that after controlling for age, gender, glucose, triglycerides, and systolic blood pressure, cocaine use was associated with a 14-fold risk of cardiac steatosis (adjusted OR 13.8, 95% CI:1.1,169).
Methods
Conclusion
MRI/MRS studies were performed using a 3.0 T scanner (Tim Trio, Siemens) on 44 participants (32 cocaine users, and 12 non-users) with informed content. To measure left ventricular function, the entire heart was imaged in shortaxis orientation using a retrospectively gated TrueFisp sequence. The short-axis along with the two and four chamber views were used to position the spectroscopic volume (6-8 ml voxel)
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