Comparison of Misoprostol and Dinoprostone for elective induction of labour in nulliparous women at full term: A randomi
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Comparison of Misoprostol and Dinoprostone for elective induction of labour in nulliparous women at full term: A randomized prospective study Evangelos G Papanikolaou*1, Nikos Plachouras1, Aikaterini Drougia2, Styliani Andronikou2, Christina Vlachou1, Theodoros Stefos1, Evangelos Paraskevaidis1 and Konstantinos Zikopoulos1 Address: 1Department of Obstetrics and Gynecology, University Hospital of Ioannina, Medical School of Ioannina, Ioannina, Greece and 2Department of Neonatology, University Hospital of Ioannina, Medical School of Ioannina, Ioannina, Greece Email: Evangelos G Papanikolaou* - [email protected]; Nikos Plachouras - [email protected]; Aikaterini Drougia - [email protected]; Styliani Andronikou - [email protected]; Christina Vlachou - [email protected]; Theodoros Stefos - [email protected]; Evangelos Paraskevaidis - [email protected]; Konstantinos Zikopoulos - [email protected] * Corresponding author
Published: 27 September 2004 Reproductive Biology and Endocrinology 2004, 2:70
doi:10.1186/1477-7827-2-70
Received: 12 July 2004 Accepted: 27 September 2004
This article is available from: http://www.rbej.com/content/2/1/70 © 2004 Papanikolaou et al; licensee BioMed Central Ltd. This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract Background: The objective of this randomized prospective study was to compare the efficacy of 50 mcg vaginal misoprostol and 3 mg dinoprostone, administered every nine hours for a maximum of three doses, for elective induction of labor in a specific cohort of nulliparous women with an unfavorable cervix and more than 40 weeks of gestation. Material and Methods: One hundred and sixty-three pregnant women with more than 285 days of gestation were recruited and analyzed. The main outcome measures were time from induction to delivery and incidence of vaginal delivery within 12 and 24 hours. Admission rate to the neonatal intensive care unit within 24 hours post delivery was a secondary outcome. Results: The induction-delivery interval was significantly lower in the misoprostol group than in the dinoprostone group (11.9 h vs. 15.5 h, p < 0.001). With misoprostol, more women delivered within 12 hours (57.5% vs. 32.5%, p < 0.01) and 24 hours (98.7% vs. 91.4%, p < 0.05), spontaneous rupture of the membranes occurred more frequently (38.8% vs. 20.5%, p < 0.05), there was less need for oxytocin augmentation (65.8% vs. 81.5%, p < 0.05) and fewer additional doses were required (7.5% vs. 22%, p < 0.05). Although not statistically significant, a lower Caesarean section (CS) rate was observed with misoprostol (7.5% vs. 13.3%, p > 0.05) but with the disadvantage of higher abnormal fetal heart rate (FHR) tracings (22.5% vs. 12%, p > 0.05). From the misoprostol group mor
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