Safety of misoprostol for near-term and term induction in small-for-gestational-age pregnancies compared to dinoprostone
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MATERNAL-FETAL MEDICINE
Safety of misoprostol for near‑term and term induction in small‑for‑gestational‑age pregnancies compared to dinoprostone and primary cesarean section: results of a retrospective cohort study Joscha Steetskamp1 · Elisabeth Bachmann1 · Annette Hasenburg1 · Marco Johannes Battista1 Received: 1 July 2019 / Accepted: 25 July 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Objectives Small-for-gestational-age (SGA) pregnancy is a condition often leading to labor induction due to concerns about the possibility of an increased risk for fetal morbidity and mortality. In this retrospective cohort study, we try to evaluate the safety of oral misoprostol for labor induction in near-term and term pregnancies in SGA fetuses compared to dinoprostone as well as to planned primary cesarean section. Materials and methods Retrospective analysis of labor indution and primary cesarean section in SGA pregnancies 37 weeks and beyond in a tertiary care centre. In total, 284 consecutive patients with SGA fetuses were included. 80 recieved oral misoprostol, 85 dinoprostone as vaginal Gel and 119 were delivered by means of primary cesarean section. Primary endpoints were umbilical aterial pH and APGAR 5′. Secondary endpoints were APGAR 1′ and 10′, rates of relevant acidosis with a pH
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