Computer Simulation and Data Analysis in Molecular Biology and Biophysics

This book provides an introduction, suitable for advanced undergraduates and beginning graduate students, to two important aspects of molecular biology and biophysics: computer simulation and data analysis. It introduces tools to enable readers to learn a

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biological and medical physics, biomedical engineering The fields of biological and medical physics and biomedical engineering are broad, multidisciplinary and dynamic. They lie at the crossroads of frontier research in physics, biology, chemistry, and medicine. The Biological and Medical Physics, Biomedical Engineering Series is intended to be comprehensive, covering a broad range of topics important to the study of the physical, chemical and biological sciences. Its goal is to provide scientists and engineers with textbooks, monographs, and reference works to address the growing need for information. Books in the series emphasize established and emergent areas of science including molecular, membrane, and mathematical biophysics; photosynthetic energy harvesting and conversion; information processing; physical principles of genetics; sensory communications; automata networks, neural networks, and cellular automata. Equally important will be coverage of applied aspects of biological and medical physics and biomedical engineering such as molecular electronic components and devices, biosensors, medicine, imaging, physical principles of renewable energy production, advanced prostheses, and environmental control and engineering.

Editor-in-Chief: Elias Greenbaum, Oak Ridge National Laboratory, Oak Ridge, Tennessee, USA

Editorial Board: Masuo Aizawa, Department of Bioengineering, Tokyo Institute of Technology, Yokohama, Japan

Judith Herzfeld, Department of Chemistry, Brandeis University, Waltham, Massachusetts, USA

Olaf S. Andersen, Department of Physiology, Biophysics & Molecular Medicine, Cornell University, New York, USA

Mark S. Humayun, Doheny Eye Institute, Los Angeles, California, USA

Robert H. Austin, Department of Physics, Princeton University, Princeton, New Jersey, USA

Pierre Joliot, Institute de Biologie Physico-Chimique, Fondation Edmond de Rothschild, Paris, France

James Barber, Department of Biochemistry, Imperial College of Science, Technology and Medicine, London, England

Lajos Keszthelyi, Institute of Biophysics, Hungarian Academy of Sciences, Szeged, Hungary

Howard C. Berg, Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, USA Victor Bloomf ield, Department of Biochemistry, Molecular Biology, and Biophysics University of Minnesota, Minneapolis, USA Robert Callender, Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, USA

Robert S. Knox, Department of Physics and Astronomy, University of Rochester, Rochester, New York, USA Aaron Lewis, Department of Applied Physics, Hebrew University, Jerusalem, Israel Stuart M. Lindsay, Department of Physics and Astronomy, Arizona State University, Tempe, Arizona, USA David Mauzerall, Rockefeller University, New York, New York, USA

Britton Chance, Department of Biochemistry/ Biophysics, University of Pennsylvania, Philadelphia, Pennsylvania, USA

Eugenie V. Mielczarek, Department of Physics and Astronomy, Geo