Control of Adhesion GPCR Function Through Proteolytic Processing
Open image in new window Proteolytic processing events in adhesion GPCRs. aGPCRs can undergo multiple autoproteolytic (red asterisks) and proteolytic processing events by exogenous proteases (yellow asterisks) that may be involved in signaling events of t
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Graphical Abstract
Proteolytic processing events in adhesion GPCRs. aGPCRs can undergo multiple autoproteolytic (red asterisks) and proteolytic processing events by exogenous proteases (yellow asterisks) that may be involved in signaling events of the receptors.
Contents 1 Forms of Proteolytic Processing Events in aGPCRs . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 85 1.1 GAIN-Mediated GPS Cleavage . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 85 1.2 Other Autoproteolytic Cleavages of aGPCRs . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 88
M. Nieberler • R.J. Kittel • T. Langenhan (*) Department of Neurophysiology, Institute of Physiology, University of W€ urzburg, R€ ontgenring 9, W€urzburg 97070, Germany e-mail: [email protected] # Springer International Publishing AG 2016 T. Langenhan, T. Scho¨neberg (eds.), Adhesion G Protein-coupled Receptors, Handbook of Experimental Pharmacology 234, DOI 10.1007/978-3-319-41523-9_5
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1.3 Cleavage of aGPCRs by Other Proteases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 89 2 Biological Effects Controlled Through aGPCR Proteolysis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 90 2.1 Trafficking . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 90 2.2 Terminating Adhesion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 91 2.3 Triggering Metabotropic Signaling . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 91 2.4 Liberation of NTF for Cell-Non-autonomous Effects . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 93 3 Similarities and Differences to Other Proteolysis-Dependent Signaling Pathways . . . . . . . 95 3.1 Protease-Activated Receptors (PARs) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 97 3.2 Notch . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 97 3.3 Ephrins . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 99 3.4 Polycystins . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 100 4 Conclusions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 101 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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