Correlation between osteoarthritis and monocyte chemotactic protein-1 expression: a meta-analysis
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(2020) 15:516
SYSTEMATIC REVIEW
Open Access
Correlation between osteoarthritis and monocyte chemotactic protein-1 expression: a meta-analysis Feifei Ni1 , Yanchao Zhang2, Xiaoxiao Peng3 and Jianjun Li1*
Abstract Objective: We evaluated the association between monocyte chemotactic protein-1 (MCP-1) and osteoarthritis. Methods: We searched PubMed, Cochrane Library, Embase, Web of Science, China National Knowledge Infrastructure (CNKI), VIP (Chinese database), and Wan Fang (Chinese database) (before May 10, 2020), with no language limitations. STATA version 12.0 and Revman version 5.3 were used for data analysis. The standard mean difference (SMD) and corresponding 95% confidence intervals (95% CIs) were calculated. Nine clinical studies, including 376 patients with osteoarthritis and 306 healthy controls, were evaluated. Results: The combined SMDs of MCP-1 expression levels suggested that MCP-1 expression was significantly higher in patients with osteoarthritis than healthy controls (SMD = 1.97, 95% CI = 0.66–3.28, p = 0.003). Moreover, subgroup analysis implied that osteoarthritis patients from both Asians and mixed populations had higher MCP-1 expression levels than controls, whereas Caucasians did not (p > 0.05). Serum MCP-1 levels (SMD = 2.83, 95% CI = 1.07–4.6, p < 0.00001) were significantly higher in patients with osteoarthritis than in controls; however, this difference was not significant in synovial fluid and cartilage tissue. Subgroup analysis for ethnicity showed that MCP-1 levels were significantly higher in Chinese, Dutch, and Brazilian patients with osteoarthritis than in control groups, although significant differences were not observed for American and Italian subgroups. Conclusions: Our meta-analysis demonstrated that MCP-1 expression levels were higher in patients with osteoarthritis than in healthy controls and that MCP-1 may play important roles in the progression of osteoarthritis. Serum MCP-1 levels may serve as a potential biomarker for the diagnosis of osteoarthritis. Keywords: Osteoarthritis, Monocyte chemotactic protein-1, Meta-analysis
Introduction Osteoarthritis (OA) is a type of degenerative articular cartilage disease related to inflammation and is characterized by joint stiffness and pain. OA is most prevalent in middle-aged and elderly individuals, and its incidence has increased in recent years. In patients with OA, joint activity is significantly reduced. If not effectively * Correspondence: [email protected] 1 Department of Orthopaedics, Shengjing Hospital of China Medical University, Sanhao Street No. 36, Heping District, Shenyang 110004, Liaoning, People’s Republic of China Full list of author information is available at the end of the article
controlled in a timely manner, OA can cause limb dysfunction and affect the patient’s quality of life [1]. The incidence of osteoarthritis varies in different joints; the most common joint to be affected is the knee, followed by the hip; epidemiological studies have found that the global incidence of OA in the knee is 3.8%, whereas
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