Derma rollers in therapy: the transition from cosmetics to transdermal drug delivery
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Derma rollers in therapy: the transition from cosmetics to transdermal drug delivery Leonna Dsouza 1 & Vivek M. Ghate 1 & Shaila A. Lewis 1 Accepted: 13 October 2020 # The Author(s) 2020
Abstract Derma roller, a device rolled onto the skin to form micropores, is extensively used for cosmetic purposes. The pores thus created are utilized to either result in the induction of collagen production, leading to glowing and wrinkle-free skin or for permeating the applied formulations to the site of action within the skin. Recent studies have shown the benefits of using derma rollers for transdermal delivery of drugs. In the nascent stage, this approach paves a way to successfully breach the stratum corneum and aid in the movement of medications directed towards the dermis and the hair follicles. The review essentially summarizes the evidence of the use of derma rollers in cosmetic setup, their designing, and the preclinical and clinical reports of efficacy, safety, and concerns when translated for pharmaceutical purposes and transdermal drug delivery. Keywords Derma rollers . Micro-needling . Cosmetics . Transdermal drug delivery . Skin . Micropores
1 Introduction Microneedling, a term familiar to most dermatologists today, has continuously evolved since its inception in the early twentieth century. The technique of microneedling is built upon non-pathogenic puncturing of the skin with micro-sized needles, thereby stimulating the underlying cells to increase the production of growth factors and the vital dermal ingredient, collagen (Aust et al. 2008; Hou et al. 2017). The use of microneedles is painless relative to the conventional hypodermic needles since they cannot penetrate the dermis layer (Azmana et al., 2020). Using microneedles also reduces trypanophobia (needle phobia) related to the use of hypodermic needles for parenteral delivery (Jamaledin et al., 2020). Dermatologists accept significant microneedling applications in the antiaging and reversal of wrinkles, and as a rejuvenating therapy for smooth and youthful-looking skin (Alster and Graham 2018; Ramaut et al. 2018; Singh and Yadav 2016). As a cosmetic treatment option, microneedling also overcomes the scars caused by injury to the skin resulting from acne, surgery, keloids, and stretch marks, and the most
* Shaila A. Lewis [email protected] 1
Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka 576104, India
prominent and difficult to counter problems of hair loss and regrowth. Though there exist non-invasive techniques to address the above cosmetic conditions, including dermabrasion, chemical peeling, and laser therapy, they are inherent with a high risk of depigmentation, additional scarring of the skin, and the undesired clinical outcomes (Chandrashekar et al. 2014). The limitation such as needle injury, phobia, need of specially qualified personnel, which will also raise the delivery costs posed by traditional dosage forms such as intradermal and intravenous injectio
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