Evaluating the efficacy of different curcumin polymorphs in transdermal drug delivery
- PDF / 1,330,422 Bytes
- 10 Pages / 595.276 x 790.866 pts Page_size
- 105 Downloads / 189 Views
Journal of Pharmaceutical Investigation https://doi.org/10.1007/s40005-020-00496-7
ORIGINAL ARTICLE
Evaluating the efficacy of different curcumin polymorphs in transdermal drug delivery Komal Upendra Pandey1 · Amita Joshi2 · Sameer Vishvanath Dalvi1 Received: 20 April 2020 / Accepted: 18 August 2020 © The Korean Society of Pharmaceutical Sciences and Technology 2020
Abstract Purpose Curcumin exists in three polymorphic forms: one monoclinic form and two orthorhombic forms. This work aims to investigate the efficacy of curcumin polymorphs in transdermal drug delivery by formulating curcumin polymorphs and their incorporation in polymeric films. Methods Monoclinic form, Form 1, was precipitated by liquid antisolvent technique from acetone solutions, whereas orthorhombic form, Form 2, was obtained by vacuum evaporation of solutions of curcumin in a mixed solvent of chloroform and hexane (60:40%v/v). The other orthorhombic form, Form 3, was precipitated from dimethylsulfoxide solutions. All three curcumin polymorphs were incorporated into polymeric films made of low molecular weight hydroxypropyl methyl cellulose (HPMC E5LV) along with different plasticizers, and permeation enhancers. Radical scavenging activity and cytotoxicity of curcumin polymorphs on human melanoma cell lines were evaluated. Water uptake, in-vitro release, and in-vitro permeation studies on HPMC films loaded with curcumin polymorph were carried out. Results Cytotoxicity studies on human melanoma cells (SK-MEL-28) showed that Form 2 results in the highest cell inhibition. Among all three curcumin polymorphs, the free radical scavenging activity of Form 3 was found to be the highest. HPMC films loaded with Form 3 exhibited higher water uptake and higher curcumin release profiles at pH of 5.5 (95.3% in 20 h) and pH 7.4 (79.8% in 20 h) as well as the highest in-vitro permeation compared to the other two curcumin forms. Conclusion Overall, orthorhombic curcumin polymorphs (i.e., Form 2 and Form 3) showed a higher propensity for transdermal drug delivery as compared to the monoclinic curcumin (Form 1). Keywords Curcumin polymorphs · HPMC films · Transdermal drug delivery · Human melanoma · Drug release · Drug permeation
Introduction Many active pharmaceutical ingredients (API) exhibit low water solubility and poor dissolution rates despite possessing good medicinal properties, which limits their bioavailability. It has been shown that by increasing specific surface area Electronic supplementary material The online version of this article (https://doi.org/10.1007/s40005-020-00496-7) contains supplementary material, which is available to authorized users. * Sameer Vishvanath Dalvi [email protected] 1
Chemical Engineering, Indian Institute of Technology Gandhinagar, Palaj, Gujarat 382355, India
Department of Pharmaceutics, B.V. Patel Pharmaceutical Education and Research Development (PERD) Centre, Thaltej, Ahmedabad, Gujarat 380054, India
2
by reduction in the particle size, dissolution rates of such APIs can be significantly enha
Data Loading...
