Development of a novel electrochemical sensor using the FeNi 3 /CuS/BiOCl nanocomposite for determination of naproxen
- PDF / 3,712,359 Bytes
- 13 Pages / 595.276 x 790.866 pts Page_size
- 48 Downloads / 215 Views
Development of a novel electrochemical sensor using the FeNi3/CuS/ BiOCl nanocomposite for determination of naproxen Peyman Mohammadzadeh Jahani1 · Hamid Akbari Javar2 · Hadi Mahmoudi‑Moghaddam3 Received: 13 March 2020 / Revised: 17 June 2020 / Accepted: 26 June 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract This study designed an electrochemical sensor to determine naproxen (NPX) via modification of a carbon paste electrode (CPE) with the FeNi3/CuS/BiOCl nanocomposite. Therefore, scanning electron microscopy (SEM), X-ray diffraction (XRD), and energy-dispersive X-ray spectroscopy (EDS) analyses characterizes the morphology and chemical compositions of FeNi3/ CuS/BiOCl as a novel nanocomposite. In addition, differential pulse voltammetry (DPV) and cyclic voltammetry (CV) have been used to analyze the electro-analytical function of F eNi3/CuS/BiOCl/CPE toward oxidizing the NPX. According to the findings, our sensor had reasonable potent of sensing NPX with a linear range of 0.2–500.0 µM and a limit of detection (LOD) of 0.06 µM. Finally, functional utility of our new modified electrode has been utilized to analyze the NPX in the urine, NPX tablet and water samples with acceptable recovery.
1 Introduction Naproxen (2-(6-methoxy-naphthalen-2-yl)propionic acid) (Scheme 1) is one of the arylpropionic acids belonging to a class of medicines known as the nonsteroidal anti-inflammatory ones that has a widespread usage for relieving the mild to moderate pains and treating the rheumatoid and osteoarthritis [1]. However, as this drug is extensively used with the physicians’ prescriptions, diverse concentration of NPX has been detected in the surface water, ground water, and wastewater, as well as in drinking water ranging between ng L− 1 to several µg L− 1 [2]. Moreover, NPX can result in the gastrointestinal and kidney issues as well as greater risks of the cardiovascular diseases, in particular, in a case of lengthy utilization of the drug or when the patient suffers from a heart disease [3]. Therefore, designing techniques to detect NPX with the high selectivity, sensitivity, and accuracy in the biological, drug, and water samples is a crucial task.
* Hadi Mahmoudi‑Moghaddam [email protected] 1
School of Medicine, Bam University of Medical Sciences, Bam, Iran
2
Pharmaceutics Department, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
3
Environmental Health Engineering Research Center, Kerman University of Medical Sciences, Kerman, Iran
A lot of researchers considered developing some techniques to detect NPX like UV–vis spectrophotometry [4], spectrofluorometric [5], liquid chromatography [6], ion selective electrodes [7], chemiluminescence [8], highperformance liquid chromatography (HPLC) [9] capillary electrophoresis [10] and voltammetry [11]. In general, the mentioned analytical procedures demand laborious sample treatment processes like solvents and liquid-liquid extraction, excipient precipitation, and the sample cleaning stages th
Data Loading...
