Dietary total antioxidant capacity is inversely associated with depression, anxiety and some oxidative stress biomarkers
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PRIMARY RESEARCH
Annals of General Psychiatry Open Access
Dietary total antioxidant capacity is inversely associated with depression, anxiety and some oxidative stress biomarkers in postmenopausal women: a cross‑sectional study Maryam Abshirini1,2, Fereydoun Siassi1*, Fariba Koohdani3, Mostafa Qorbani4,5, Hadis Mozaffari1,2, Zahra Aslani1,2, Mahshid Soleymani1, Mahdieh Entezarian1 and Gity Sotoudeh1*
Abstract Background: Postmenopausal women are at higher risk of mental disorders. Oxidative stress has implication in the development of these disorders. Dietary total antioxidant capacity (DTAC) has been proposed as a tool for assessing dietary antioxidants intake. The relationship between DTAC with depression, anxiety and stress has not been investigated in postmenopausal women. Thus, we aimed to assess the association between DTAC and depression, stress and anxiety as well as oxidative stress biomarkers. Methods: This cross-sectional study was carried out on 175 postmenopausal women. Data on dietary intake and mental health were collected by 147-item semi-quantitative food frequency questionnaires (FFQ) and Depression Anxiety Stress Scales (DASS-42), respectively. Dietary and serum total antioxidant capacity (TAC), malondialdehyde (MDA), oxidized-LDL, and superoxide dismutase (SOD) were measured. ANOVA test was applied to compare the mean of variables across the tertiles of DTAC. The relationship between DTAC and oxidative stress biomarkers was determined through ANCOVA method. Simple and multivariate linear regression tests were performed to measure the relationship between DTAC and mental health. Results: Serum MDA level was significantly lower in the subjects at the highest tertiles of DTAC (P-value
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