DNA Methylation Molecular Biology and Biological Significance
The occurrence of 5-methylcytosine in DNA was first described in 1948 by Hotchkiss (see first chapter). Recognition of its possible physiologi cal role in eucaryotes was first suggested in 1964 by Srinivasan and Borek (see first chapter). Since then work
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DNA Methylation Molecular Biology and Biological Significance
Edited by J. P. Jost
H. P. Saluz
Birkhauser Verlag Basel • Boston • Berlin
Editors' addresses: Dr. Jean-Pierre Jost Friedrich Miescher-Institut P.O. Box 2543 CH-4002 Basel Switzerland
Dr. Hans-Peter Saluz IRBM Via Pontina Km 30,600 1-00040 Pomezia (Roma) Italy
Library of Congress Cataloging-in-Publication Data DNA methylation: molecular biology and biological significance / edited by J.P. Jost, H.P. Saluz. -- (EXS; 64) Includes bibliographical references and index. ISBN -13: 978-3-0348-9915-4 1. DNA-Methylation. I. Jost, J. P. (Jean-Pierre), 1937II. Saluz, H. P., 1952- . III. Series. [DNLM: 1. DNA-metabolism. 2. Methylation. WI E65 v. 64 / QU 58 D629] QP624.D63 1993 574.8T3282-dc20 Deutsche Bibliothek Cataloging-in-Publication Data DNA methylation: molecular biology and biological significance / ed. by J. P. Jost; H. P. Saluz. - Basel; Boston; Berlin: Birkhiiuser, 1993 (EXS; 64) ISBN -13: 978-3-0348-9915-4 e-ISBN-13: 978-3-0348-9118- 9 DOl: 10.1 007/978-3-0348 -9118-9 NE: Jost, Jean-Pierre [Hrsg.]; GT The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher cannot assume any legal responsibility for given data, especially as far as directions for the use and the handling of chemicals and drugs are concerned. This information can be obtained from the manufacturers. This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically those of translation, reprinting, re-use of illustrations, broadcasting, reproduction by photocopying machine or similar means, and storage in data banks. Under §54 of the German Copyright Law, where copies are made for other than private use, a fee is payable to 'Verwertungsgesellschaft Wort', Munich.
© 1993 Birkhiiuser Verlag
P.O. Box 133 CH-4010 Basel Switzerland Softcover reprint of the hardcover 1st edition 1993
ISBN -13: 978-3-0348-9915-4
"A beautiful model or theory may not be right, but an ugly one must be wrong". Jacques Monod in: Symmetry and function of biological systems at the macromolecular level. Nobel Symposium 11, 1969. . . ."Juger des problemes devenus murs pour l'analyse, decider quand il est temps d'explorer Ii nouveau un vieux territoire, reprendre des questions naguere considerees comme resolues ou insolubles, tout cela constitue l'une des qualites majeures d'un scientifique" ... Fran(j:ois Jacob in: Le Jeu des Possibles, Essai sur la diversite du vivant.
Contents A. Weissbach A chronicle of DNA methylation (1948-1975)................
1
H. P. Saluz and J. P. Jost Major techniques to study DNA methylation. . . . . . . . . . . . . . . . .
11
W. Zacharias Methylation of cytosine influences the DNA structure . . . . . . . . .
27
M. Noyer- Weidner and T. A. Trautner Methylation of DNA in prokaryotes . . . . . . . . . . . . . . . . . . .
