DNA-Protein Interactions Principles and Protocols, Third Edition
Gene expression can mean the difference between a functional and non-functional genome, between health and disease, and with the development of transgenic crops, the difference between survival and starvation. In DNA-Protein Interactions: Principles and P
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IN
MOLECULAR BIOLOGY™
Series Editor John M. Walker School of Life Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
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DNA-Protein Interactions Principles and Protocols Third Edition
Edited by
Tom Moss*and Benoît Leblanc† †
* Centre de Recherche en Cancérologie de l’Université Laval, Québec City, QC, Canada Département de Biologie, Faculté des Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada
Editors Tom Moss Centre de Recherche en Cancérologie de I´Université Laval Québec City, QC Canada
Benoît Leblanc Département de Biologie Faculté des Sciences Université de Sherbrooke Sherbrooke, QC Canada
ISSN: 1064-3745 e-ISSN: 1940-6029 ISBN: 978-1-60327-014-4 e-ISBN: 978-1-60327-015-1 DOI: 10.1007/978-1-60327-015-1 Springer Dordrecht Heidelberg London New York Library of Congress Control Number: 2008942788 © Humana Press, a part of Springer Science+Business Media, LLC 2009 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is for-bidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with re-spect to the material contained herein. Cover Background Image: Chapter 22, Fig. 5A. Evaluation and exploitation of a 2-D crystallization experiment. Histidine-tagged yeast RNA polymerase I is incubated with nickel chelating lipids. (A) Low magnification electron microscopy image showing the organization of the protein complex into domains. The bar represents 5 µm Cover Inset Images: Chapter 1, Fig. 1. The structure of the minimal MetJ repressor-operator complex (pdb 1cma). The sequence of the consensus two met box operator (top strand) is shown alongside from 5’ (top) to 3’ (bottom). The repressor is shown as a ribbon representation with one subunit shaded. The corepressor molecules (AdoMet) are shown as ball and stick representations and the DNA operator is a framework model. (I am grateful to Prof. Simon Phillips and his colleagues for production of this figure.) Chapter 9, Fig. 3. Summary of the results. Bottom: Space filling representation of the operator site showing the positions where ethyl
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