Mitochondrial DNA Methods and Protocols
This third edition is comprised of well-established protocols that are considered the gold standard in the field as well as new methodologies for mitochondrial DNA analysis. of Mitochondrial DNA: Methods and Protocols describes protocols for detecting mut
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Matthew McKenzie Editor
Mitochondrial DNA Methods and Protocols Third Edition
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Mitochondrial DNA Methods and Protocols Third Edition
Edited by
Matthew McKenzie Hudson Institute of Medical Research, Clayton, VIC, Melbourne, Australia
Editor Matthew McKenzie Hudson Institute of Medical Research Clayton, VIC, Melbourne, Australia
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-3039-5 ISBN 978-1-4939-3040-1 (eBook) DOI 10.1007/978-1-4939-3040-1 Library of Congress Control Number: 2015947277 Springer New York Heidelberg Dordrecht London © Springer Science+Business Media New York 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Humana Press is a brand of Springer Springer Science+Business Media LLC New York is part of Springer Science+Business Media (www.springer.com)
Preface Since the publication of the second edition of Mitochondrial DNA: Methods and Protocols, major technological advances have been made in high-throughput DNA sequencing, highresolution cellular imaging, and the use of targeted nucleases for genetic manipulation. These new scientific tools have revolutionized the study of human genetics and biology and apply equally to the investigation of the mitochondrial genome. This has allowed researchers to gain new insights into how mitochondrial DNA modulates mitochondrial metabolism and also the association between mitochondrial DNA variation and human disease. This third edition of Mitochondrial DNA: Methods and Protocols describes these new methodologies for mitochondrial DNA analysis and, combined with well-established protocols that are considered the gold standard in the field, comprises a compendium of detailed methods for the study of mitochondrial DNA biology. The
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