Effect of Essential Oil of Zhumeria majdae on Morphine Tolerance and Dependence in Mice
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C
hinese Journal of Integrative Medicine
Available online at link.springer.com/journal/11655 Journal homepage: www.cjim.cn/zxyjhen/zxyjhen/ch/index.aspx E-mail: [email protected]
Original Article
Effect of Essential Oil of Zhumeria majdae on Morphine Tolerance and Dependence in Mice Zahra Ehtemami1, Hamed Shafaroodi2, and Jinous Asgarpanah1 Objective:: To evaluate the effects of Zhumeria majdae essential oil (ZMEO) on morphine ABSTRACT Objective Methods:: ZMEO (10, 20, and 40 mg/kg) and clonidine (0.1 mg/kg) as the dependence and tolerance in mice. Methods positive control were injected intraperitoneally (i.p.). The effect of ZMEO and clonidine on the dependence were evaluated by counting the number of jumps induced by naloxone (5 mg/kg) while the tolerance was evaluated Results:: ZMEO at the dose of 10 mg/kg during the development period led to a significant by the tail-flick test. Results inhibition of morphine tolerance (P
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