Effect of Helicobacter pylori eradication after subtotal gastrectomy on the survival rate of patients with gastric cance
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ORIGINAL ARTICLE
Effect of Helicobacter pylori eradication after subtotal gastrectomy on the survival rate of patients with gastric cancer: follow‑up for up to 15 years Yonghoon Choi1 · Nayoung Kim1,6 · Chang Yong Yun1 · Yoon Jin Choi1 · Hyuk Yoon1 · Cheol Min Shin1 · Young Soo Park1 · Sang‑Hoon Ahn2 · Do Joong Park2,7 · Hye Seung Lee3,8 · Ji‑Won Kim4 · Jin Won Kim4 · Keun‑Wook Lee4,6 · Won Chang5 · Ji Hoon Park5 · Yoon Jin Lee5 · Kyoung Ho Lee5,9 · Young Hoon Kim5,9 · Dong Ho Lee1,6 · Hyung‑Ho Kim2,7 Received: 18 March 2020 / Accepted: 21 April 2020 © The International Gastric Cancer Association and The Japanese Gastric Cancer Association 2020
Abstract Objective Helicobacter pylori (HP) is known to play an important role in the development of gastric cancer (GC). The aim of this study was to analyze the effect of HP eradication on the survival rate and cancer recurrence in patients who underwent subtotal gastrectomy for GC. Design Totally 1,031 patients diagnosed with gastric adenocarcinoma who received surgical treatment at the Seoul National University Bundang Hospital from 2003 to 2017 and positive for HP infection were analyzed. The overall and GC-related survival according to HP eradication were compared; risk factors for GC-specific death and cancer recurrence were analyzed, and propensity score matching (PSM) was performed. Results Statistically significant benefits of overall and GC-specific survival were observed in the eradicated group compared to the non-eradicated group (P
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