Effect of Surgical Removal of Testicles and Adrenal Glands on Ultradian Rhythms of Body Temperature in Male Wistar Rats
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Bulletin of Experimental Biology and Medicine, Vol. 169, No. 5, September, 2020
691
EXPERIMENTAL METHODS FOR CLINICAL PRACTICE Effect of Surgical Removal of Testicles and Adrenal Glands on Ultradian Rhythms of Body Temperature in Male Wistar Rats under Conditions of Constant Illumination M. E. Diatroptov1, M. A. Diatroptova2, and A. M. Kosyreva2
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 169, No. 5, pp. 623-626, May, 2020 Original article submitted October 29, 2019 We have studied body temperature dynamics of mature male Wistar rats maintained under constant illumination after surgical removal of the testicles and adrenal glands. In gonadectomized animals, pronounced increases in body temperature (>0.9°C) were observed every 4-6 h; during the periods 03.35-04.30, 07.35-08.30, 11.35-12.30, 15.35-16.30, 19.35-20.30, and 23.35-00.30, they were recorded 1.5-fold more often than during the rest periods. These results do not significantly differ from the parameters of the control group. Combined removal of the testicles and adrenal glands led to shortening of main period of temperature oscillations to 4-4.5 h and a decrease in its amplitude; pronounced increase in body temperature (>0.5°C) was observed 2.1 times more often during the periods 03.35-04.30, 07.35-08.30, 11.35-12.30, 15.35-16.30, 19.35-20.30, and 23.35-00.30 than in other time intervals. Thus, the removal of the testicles and adrenal glands does not violate the 4-h intraday rhythm of body temperature. Key Words: ultradian rhythm; body temperature; gonadectomy; adrenalectomy; rats
Much attention is now paid to studying the mechanisms of formation of ultradian biorhythms with periods of 1-6 h, and their connection with the main pacemakers of organism’s rhythms [6,8]. It is believed that the dopaminergic system of the brain is involved in the mechanisms of formation of ultradian biorhythms [5]. It was established that disruption of the suprachiasmatic nucleus of the hypothalamus did not violate the ultradian rhythm of corticosterone secretion [10]. Constant illumination that lengthens the circadian rhythm in hamsters, does not change the period of ultradian rhythms [9]. Hence, this dopaminergic oscillator is autonomous and is not governed by the circadian system of the organism. A. N. Severtsov Institute of Ecology and Evolution, Russian Academy of Science; 2Research Institute of Human Morphology, Moscow, Russia. Address for correspondence: [email protected]. M. E. Diatropov 1
We had previously found in male Wistar rats kept at constant illumination, the daily dynamics of body temperature indicators summed up over 2023-day intervals (the period during which the near 25-h free-flowing circadian rhythm is 24 h ahead of the 24-h daily rhythm) has 4-h intraday rhythm with maximum rises at 3.35-4.30, 7.35-8.30, 11.35-12.30, 15.35-16.30, 19.35-20.30 and 23.35-00.30 [2]. Du ring these hours, sharp increases in body temperature were significantly more often observed. Therefore, in some periods during the day, the episodes of body tempe
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