Effect of xylan sulfate on the responsive swelling behavior of poly(methacrylatoethyl trimethyl ammonium chloride)-based
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ORIGINAL RESEARCH
Effect of xylan sulfate on the responsive swelling behavior of poly(methacrylatoethyl trimethyl ammonium chloride)based composite hydrogels Ming Li . Xiangxiang Sun . Yanjun Chen . Tao Shen . Zhuotao Tan . Chenglun Tang . Wei Zhuang . Chenjie Zhu . Hanjie Ying
Received: 7 January 2020 / Accepted: 13 August 2020 Ó Springer Nature B.V. 2020
Abstract Xylan sulfate, one important xylan derivative, was prepared using microfluidic reactor system and incorporated in situ under the polymerization of methacroylcholine chloride (DMC), resulting in composite hydrogels containing variable amount of xylan sulfate. The introduction of xylan sulfate imparts enhanced temperature-swelling responsiveness to the hydrogels, and substantially increases their water swelling ratio up to [ 200 g/g, which is twice higher than the neat polyDMC hydrogel. Such swelling behavior may relate to the electrostatic interaction between the –SO3- in xylan sulfate and the –NH4? in
polyDMC. This interaction significantly improves the formation of porous architecture and the tensile toughness of the hydrogels. The composite hydrogels exhibit responsive swelling behavior at different salt, pH, and solvent conditions due to osmotic pressure decline, charge shielding and salting-out effect. They load 2.2 times amount of tetracycline hydrochloride and show 50.3% slower release rate than the neat polyDMC hydrogel, which shows great potential for drug delivery applications.
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s10570-020-03402-4) contains supplementary material, which is available to authorized users. M. Li X. Sun Y. Chen T. Shen Z. Tan C. Tang W. Zhuang (&) C. Zhu (&) H. Ying College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, China e-mail: [email protected] C. Zhu e-mail: [email protected]
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Cellulose
Graphic abstract
Keywords Responsive hydrogels Xylan sulfate Swelling behavior Electrostatic interaction Drug release
Introduction Hemicelluloses, the main components inside the cell walls of plants, are the second-most abundant polysaccharides in biomass resources. Developing hemicellulose-based high-value products is critical in improving the value and the sustainability of integrated biorefineries, and therefore is highly desirable (Ebringerova´ et al. 2005). Hemicelluloses are usually obtained as byproducts from viscose fiber and pulp industry, and have been studied towards monosaccharide-based food additives and fine chemicals under bio- or chem-catalyzed depolymerization and derivation (Naidu et al. 2018). Direct chemical modification of hemicelluloses such as esterification and etherification has been applied to alter its hydrophilicity/ hydrophobicity, resulting in biobased surfactants for food, papermaking and material fields (Petzold-Welcke et al. 2014). Recently, designing sustainable and smart hydrogels has attracted much attention, becaus
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