Effective Role of Terminalia arjuna Reduced Gold Nanoparticles on Reproductive Dysfunction Induced by Acetaminophen in M
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Effective Role of Terminalia arjuna Reduced Gold Nanoparticles on Reproductive Dysfunction Induced by Acetaminophen in Male Wistar Rat Mousumi Mitra 1 & Jaysree Laha 1 & Dilip K Nandi 1
# Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Acetaminophen is a commonly used analgesic and antipyretic agent, which causes liver and kidney damage when it is taken in high doses. It also has an adverse effect on reproductive system. Terminalia arjuna has a beneficial effect on hepato-protective properties. In this study, effect of green synthesized gold nanoparticles using Terminalia arjuna (AuNPs) has been evaluated for prevention of reproductive disorder in male Wistar rats. Then, experiment was conducted on 24 healthy male Wistar rats. Biochemical test such as sperm count, sperm viability, seminal fructose level, testicular cholesterol, superoxide dismutase (SOD), catalase (CAT), and histopathological analysis revealed that co-administration of green synthesized AuNPs along with acetaminophen showed effective significant recovery in the reproductive disorder caused due to acetaminophen toxicity. Overall, the results emphasized the promising effect of green synthesized AuNPs against acetaminophen-induced toxicity in male Wistar rats. Keywords Acetaminophen . AuNPs . Terminalia arjuna . Sperm count . Sperm viability
1 Introduction Nanomedicine is a branch of science that uses nanotechnology to monitor, maintain, treat, prevent diseases, and control the biological systems at the nanometer size range, using engineered nanostructures and nano devices [1]. Nanomedicines have huge capacity to bring benefits to wide areas of research and application. Among the metallic nanoparticles, especially, the gold nanoparticles act as a novel drug carrier in the wide areas of particle-based drug delivery system. Gold nanoparticles have huge applications in biomedicine and molecular biology, which involves biomedical [2] and cell imaging [3], peptide delivery [4], biosensing [5], and drug delivery [6]. It is preferable to use nontoxic reagents to improve the biocompatibility
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s12668-020-00737-x) contains supplementary material, which is available to authorized users. * Dilip K Nandi [email protected] 1
P.G. Dept. of Human Physiology, Department of Chemistry, Department of Nutrition, Raja Narendra Lal Khan Women’s College (Autonomous), Midnapore, West Bengal 721102, India
of gold nanoparticles. A protecting agent is also required for gold nanoparticle synthesis, whose role is to adsorb onto the surface of the newly formed nanoparticles to prevent particle agglomeration and further growth. Several publications suggest new synthesis approach of gold nanoparticles in which green reduction and protection agents were used [7]. Most of these reducing and stabilizing agents were obtained from plants [8], bacteria, algae, and fungi [9]. Terminalia arjuna, a member of Combretaceae family, is grabbing the attention of r
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