Engineering the pH-Sensitivity of the Graphene and Carbon Nanotube Based Nanomedicines in Smart Cancer Therapy by Grafti
- PDF / 3,374,344 Bytes
- 13 Pages / 595.276 x 790.866 pts Page_size
- 66 Downloads / 131 Views
RESEARCH PAPER
Engineering the pH-Sensitivity of the Graphene and Carbon Nanotube Based Nanomedicines in Smart Cancer Therapy by Grafting Trimetyl Chitosan Azadeh Khoshoei 1 & Ebrahim Ghasemy 2 & Fatemeh Poustchi 3 & Mohammad-Ali Shahbazi 4,5 Reza Maleki 6
&
Received: 6 June 2020 / Accepted: 13 July 2020 # The Author(s) 2020
ABSTRACT Purpose The aim of this study was to introduce a smart and responsive drug carrier for Doxorubicin (DOX) and Paclitaxel (PAX) for desirable therapeutic application. Method Loading and releasing of DOX and PAX from smart and pH-sensitive functionalized single-walled carbon nanotube (SWCNTs) and graphene carriers have been simulated by molecular dynamics. The influences of chitosan polymer on proposed carriers have been studied, and both carriers were functionalized with carboxyl groups to improve the loading and releasing properties of the drugs. Results The results showed that DOX could be well adsorbed on both functionalized SWCNTs and graphene. In contrast, there was a weak electrostatic and Van der Waals interaction between both these drugs and carriers at cancerous tissues, which is highly favorable for cancer therapy. Adding trimethyl chitosan (TMC) polymer to carriers facilitated DOX release Azadeh Khoshoei and Ebrahim Ghasemy contributed equally to this work. * Mohammad-Ali Shahbazi [email protected] * Reza Maleki [email protected] 1
Institute of Nano Science and Nano Technology, University of Kashan, Kashan, Iran
2
Nanotechnology Department, School of New Technologies, Iran University of Science and Technology, Tehran, Iran
3
Department of Nanotechnology, University of Guilan, Guilan, Iran
4
Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, FI-00014 Helsinki, Finland
5
Zanjan Pharmaceutical Nanotechnology Research Center (ZPNRC), Zanjan University of Medical Sciences, Zanjan 45139-56184, Iran
6
Department of Chemical Engineering, Shiraz University of Technology, Shiraz, Iran
at acidic tissues. Furthermore, at blood pH, the PAX loaded on the functionalized SWCNTs carrier represented the highest dispersion of the drug while the DOX-graphene showed the highest concentration of the drug at a point. In addition, the mean-square displacement (MSD) results of PAXgraphene indicated that the PAX could be adsorbed quickly and be released slowly. Finally, functionalized grapheneTMC-PAX is a smart drug system with responsive behavior and controllable drug release, which are essential in cancer therapy. Conclusion Simultaneous application of the carboxyl group and TMC can optimize the pH sensitivity of the SWCNTs and graphene to prepare a novel and smart drug carrier for cancer therapy.
KEY WORDS cancer therapy . graphene . molecular dynamic . nanomedicine . single walled carbon nanotube
INTRODUCTION Many new cases of cancers are being reported by the World Health Organization annually and many different efforts have been made to cure or prevent the disease (1). However, for most patients, t
Data Loading...
