Epidemiological characteristics, clinical and laboratory findings supporting preliminary diagnosis of Crimean-Congo hemo
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Wien Klin Wochenschr https://doi.org/10.1007/s00508-020-01719-5
Epidemiological characteristics, clinical and laboratory findings supporting preliminary diagnosis of CrimeanCongo hemorrhagic fever in an endemic region in Turkey Zuhal Yesilba ¸ g˘
· Aslı Karadeniz · Safiye Koçulu · Cahit Bekir Kayhan
Received: 29 January 2020 / Accepted: 9 July 2020 © Springer-Verlag GmbH Austria, part of Springer Nature 2020
Summary Background Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne disease that has various symptoms. Since rapid diagnosis is crucial for survival, understanding the characteristics of patients is important for clinicians while waiting for results. This study aimed to evaluate findings that support the preliminary diagnosis of suspected CCHF in patients and take a look at the management of CCHF in Turkey. Methods Demographics, presenting symptoms and laboratory findings of the patients admitted with a suspicion of CCHF, were recorded from the patient files and database of Ministry of Health. A diagnosis of CCHF was based on detection of immunoglobulin M (IgM) antibodies and/or viral RNA. The patients with and without CCHF were compared in terms of differences in epidemiological, clinical and laboratory findings. Results Out of 87 patients, 61 (70.1%) were CCHF and 26 (29.9%) were non-CCHF cases. Working with agriculture/livestock, tick exposure, contact with body
fluids of animals, travel to rural areas within 2 weeks, fever, headache, leucopenia, anemia, international normalized ratio (INR) elevation were significantly more common in CCHF cases. According to multivariate analysis, tick exposure (odds ratio, OR 9.03, 95% confidence interval, CI 1.96–41.47, p = 0.005), contact with body fluids of animals (OR 14.9, 95% CI 2.23–99.94, p = 0.005), leucopenia (OR 13.65, 95% CI 2.55–72.91, p = 0.02) and anemia (OR 8.41, 95% CI 1.06–66.42, p = 0.04) were independently indicative for CCHF. Conclusion As it takes a considerable time for a definitive diagnosis, determining epidemiological features and risk factors is an important step for preliminary diagnosis of CCHF as well as early implementation of precautions against nosocomial transmission of the virus.
Z. Ye¸silba˘g () Department of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Education and Research Hospital, Dr. Tevfik Saglam street, No:11, 34147 Bakırköy/Istanbul, Turkey [email protected]
Introduction
A. Karadeniz Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology, Maltepe University, Istanbul, Turkey S. Koçulu Department of Infectious Diseases and Clinical Microbiology, Florence Nightingale Hospital, Istanbul, Turkey C. B. Kayhan Health Directorate of Yozgat, Ministry of Health, Yozgat, Turkey
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Keywords Crimean-congo hemorrhagic fever · Epidemiology · Leukopenia · Risk factors · Tick exposure
Crimean-Congo hemorrhagic fever (CCHF) is a tickborne zoonotic disease caused by the CCHF virus belonging to the genus Nairovirus of the Bunyaviridae family [1–4]. The disease is acquired by an i
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