Essentials of Apoptosis A Guide for Basic and Clinical Research
As a fundamental biological process, cell death and cell survival is essential to the normal homeostasis of the organism. Our knowledge on this process has been tremendously expanded in the past two decades. Essentials of Apoptosis: A Guide for Basic and
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Xiao-Ming Yin
l
Zheng Dong
Editors
Essentials of Apoptosis A Guide for Basic and Clinical Research Second Edition
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Editors Xiao-Ming Yin Department of Pathology University of Pittsburgh 3500 Terrace Street Pittsburgh PA 15261 Scaife Hall, 7th Floor USA [email protected]
Zheng Dong Department of Graduate Studies Medical College of Georgia 1459 Laney Walker Blvd. Augusta GA 30912 USA [email protected]
ISBN 978-1-60327-380-0 e-ISBN 978-1-60327-381-7 DOI 10.1007/978-1-60327-381-7 Library of Congress Control Number: 2009921154 # Humana Press, a part of Springer ScienceþBusiness Media, LLC 2009 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer ScienceþBusiness Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Printed on acid-free paper springer.com
Preface to Second Edition
The first edition of this book was published in 2003. It was intended to provide the basic and essential information of apoptosis for those who were new to the field and who wanted to apply the knowledge to their own research. The book therefore focused on the concepts, the basic molecular architecture, and the pathophysiological significance of apoptosis. Since the first edition, there have been tremendous new developments in the field of apoptosis and cell death in general. The concept of various types of cell death has been further developed. The studies in both basic and clinical disciplines have been greatly expanded. In particular, notable progress has been made in extending the work into the therapeutic arena. As a result, the field has matured considerably and developed extensive cross-talk with works in other fields. We strive to incorporate and reflect these new developments in the second edition of this book. Our goal is to provide readers with the most updated and advanced knowledge in the field, while maintaining the fundamental information as presented in the first edition. To this end, the book has been significant expanded, not only in the page and chapter numbers but more importantly in the depth of coverage. Most of the chapters have been revised and/or rewritten, and 15 new chapters have been added to give rise to a total of 31 chapters. In Part I, in addition to the discussion of the major apoptosis molecules, the activation and regulatory pathways, and the clearance of apoptotic cells, we also present important issues that examine apoptosis from more integrated points of view. Thus, the roles of reactive
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