Esters of Maleic Anhydride as Both a New and Old Material for Tissue Engineering
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1235-RR06-08
Esters of Maleic Anhydride as Both a New and Old Material for Tissue Engineering Elizabeth L. Hedberg-Dirk1,2, Kirsten N. Cicotte2,3 ,Shawn M. Dirk3 1
Department of Chemical and Nuclear Engineering,
2
Center for Biomedical Engineering University of New Mexico, Albuquerque NM 87131
3
Organic Materials Department, Sandia National Laboratories, Albuquerque NM 87123
ABSTRACT Many publications have examined the biodegradable polymer poly(propylene fumerate) (PPF) for use in tissue engineering applications. We have examined a similar crosslinkable polymer system, poly(propylene fumerate)-co-(propylene maleate) (PPFcPM), derived from maleic anhydride (MA) and 1,2-propanediol (PD). Two methods were examined in order to synthesis the copolymer. In the first case, the reaction was carried out at high temperature (250 °C) under nitrogen using tosic acid as the catalyst. Only PPF was identified due to the thermal isomerization of the maleate groups to the more stable fumerate group. In the second case, toluene was used as the solvent to azeotropically (85 °C) remove water and drive the acid catalyzed esterification reaction. In the lower temperature case, a small amount of fumerate (
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