Europium-doped amorphous calcium phosphate porous nanospheres: preparation and application as luminescent drug carriers
- PDF / 2,046,847 Bytes
- 9 Pages / 595.276 x 793.701 pts Page_size
- 11 Downloads / 232 Views
NANO EXPRESS
Open Access
Europium-doped amorphous calcium phosphate porous nanospheres: preparation and application as luminescent drug carriers Feng Chen1, Ying-Jie Zhu1*, Kui-Hua Zhang2, Jin Wu1, Ke-Wei Wang1, Qi-Li Tang1, Xiu-Mei Mo2
Abstract Calcium phosphate is the most important inorganic constituent of biological tissues, and synthetic calcium phosphate has been widely used as biomaterials. In this study, a facile method has been developed for the fabrication of amorphous calcium phosphate (ACP)/polylactide-block-monomethoxy(polyethyleneglycol) hybrid nanoparticles and ACP porous nanospheres. Europium-doping is performed to enable photoluminescence (PL) function of ACP porous nanospheres. A high specific surface area of the europium-doped ACP (Eu3+:ACP) porous nanospheres is achieved (126.7 m2/g). PL properties of Eu3+:ACP porous nanospheres are investigated, and the most intense peak at 612 nm is observed at 5 mol% Eu3+ doping. In vitro cytotoxicity experiments indicate that the as-prepared Eu3+:ACP porous nanospheres are biocompatible. In vitro drug release experiments indicate that the ibuprofen-loaded Eu3+:ACP porous nanospheres show a slow and sustained drug release in simulated body fluid. We have found that the cumulative amount of released drug has a linear relationship with the natural logarithm of release time (ln(t)). The Eu3+:ACP porous nanospheres are bioactive, and can transform to hydroxyapatite during drug release. The PL properties of drug-loaded nanocarriers before and after drug release are also investigated. Introduction The development of multifunctional nanosystems, for maximum therapeutic benefit including early diagnoses of the diseases and delivery of suitable therapeutic drugs, holds a promise for the future of clinical treatment to enhance therapeutic efficacy [1,2]. Therefore, it is highly desirable to develop novel methods that can achieve simultaneous in vivo imaging and treatment based on nanotechnology. Nanoparticles show unique size-dependant physical and chemical properties and have great potential for clinical use [3,4]. Dual or multifunctional nanosystems can be constructed based on nanostructures with well-designed structures and constituents, which are simultaneously capable of diagnosis and treatment [5]. Many kinds of nanostructures have been fabricated from a multitude of materials and used in bio-imaging, including quantum dots [6-8], silica * Correspondence: [email protected] 1 State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, P. R. China Full list of author information is available at the end of the article
particles [9], gold [10], carbon nanotubes [11], dendrimers [12-14], magnetic nanoparticles [15-18], and so on. However, in the search for the nanosystems for bio-imaging and therapy, a couple of the major concerns are their biodegradability and toxicity [19-21]. To date, the development of multifunctional inorganic nanosystems with both biocompat
Data Loading...
