Fe 3 O 4 @ Angelica sinensis polysaccharide nanoparticles as an ultralow-toxicity contrast agent for magnetic resonance
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ORIGINAL ARTICLE
Fe3O4@Angelica sinensis polysaccharide nanoparticles as an ultralow-toxicity contrast agent for magnetic resonance imaging Kai Wang, Xiao-Guang Xu* , Ying-Li Ma, Chun-Rui Sheng, Li-Na Li*, Li-Ying Lu, Jian Wang, Yi-Ning Wang, Yong Jiang
Received: 18 July 2020 / Revised: 16 August 2020 / Accepted: 19 August 2020 Ó GRINM Bohan (Beijing) Publishing Co., Ltd 2020
Abstract Although iron oxide (Fe3O4) nanoparticles have broad application prospects as magnetic resonance imaging (MRI) contrast agent, their biocompatibility and biotoxicity still need to be improved. In this study, we prepared Fe3O4@Angelica sinensis polysaccharide nanoparticles (Fe3O4@ASP NPs) with a 9 nm Fe3O4 core and ASP as the coating material. The Fe3O4@ASP NPs are superparamagnetic, can be taken up by liver and spleen macrophages in the circulatory system in vivo, and are a good-biocompatibility and low-toxicity transverse relaxation time (T2) and T2-star (T2*) magnetic resonance imaging (MRI) contrast agent for the liver. The cytotoxicity assessment using HeLa cells and
the pathological tests in mice validate that Fe3O4@ASP NPs have low toxicity and good biocompatibility in vivo, which can be attributed to the ASP as a natural polysaccharide with good biocompatibility and its function of protecting the liver. Fe3O4@ASP NPs are a potential new MRI contrast agent with high signal intensity in vivo. Keywords Superparamagnetic nanoparticles; Fe3O4; Angelica sinensis polysaccharide; Magnetic resonance imaging; Ultralow toxicity
1 Introduction Electronic supplementary material The online version of this article (https://doi.org/10.1007/s12598-020-01620-0) contains supplementary material, which is available to authorized users. K. Wang, X.-G. Xu*, Y.-L. Ma, Y. Jiang School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083, China e-mail: [email protected] K. Wang School of Instrumentation Science and Optoelectronics Engineering, Beihang University, Beijing 100191, China C.-R. Sheng, L.-N. Li* School of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China e-mail: [email protected] L.-Y. Lu School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing 100083, China J. Wang, Y.-N. Wang Department of Radiology, Peking Union Medical College Hospital Chinese Academy of Medical Sciences, Beijing 100730, China
Currently, magnetic resonance imaging (MRI) is one of the most effective noninvasive diagnostic methods for human diseases. To improve MRI quality, the use of appropriate contrast agents is essential [1, 2]. Superparamagnetic nanoparticles, which affect the relaxation of human tissues, can be used as MRI contrast agents to enhance imaging contrast [3, 4]. Fe3O4 nanoparticles (NPs) reduce the transverse relaxation time (T2) or transverse relaxation times of the surrounding water protons due to the dipole interaction between the magnetic moment of NPs and the protons in the water and enhance contrast and sensitiv
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