Fluorescence In Situ Hybridization (FISH) Application Guide
This manual offers detailed protocols for fluorescence in situ hybridization (FISH) and comparative genomic hybridization approaches, which have been successfully used to study various aspects of genomic behavior and alterations. Methods using different p
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Fluorescence In Situ Hybridization (FISH) Application Guide Second Edition
SPRINGER PROTOCOLS HANDBOOKS
More information about this series at http://www.springer.com/series/8623
Fluorescence In Situ Hybridization (FISH) Application Guide Editor
Thomas Liehr Institut f€ur Humangenetik, Jena, Germany
Second Edition
Editor Thomas Liehr Institut f€ ur Humangenetik Jena, Germany
ISSN 1949-2448 ISSN 1949-2456 (electronic) Springer Protocols Handbooks ISBN 978-3-662-52957-7 ISBN 978-3-662-52959-1 (eBook) DOI 10.1007/978-3-662-52959-1 Library of Congress Control Number: 2016954653 © Springer-Verlag Berlin Heidelberg 2009, 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer-Verlag GmbH Berlin Heidelberg
Foreword Of all biological structures, chromosomes are the most fascinating. They embody the essence of life, containing the DNA blueprint of evolution and the source of variation in all organisms. Only by learning about chromosomes can one understand the life cycle of the cell and the mechanisms of heredity. A full appreciation of genetics and molecular biology requires knowledge of chromosome structure and function. There is beauty in the image of the chromosome, fixed, stained and observed with the compound microscope. The stains used in the discovery of bacteria in the nineteenth century led also to the serendipitous discovery of chromosomes. As methods improved, their detailed structure became more apparent. Chromosome variation in number and morphology were found to be species characteristics, and a pair associated with sex determination could be identified in many species. Each advance in chromosome biology followed an advance in chromosome technology. This is the history of cytogenetics. My fascination with chromosomes makes it a great pleasure for me to read about modern methods for examining them. The second edition of this Application Guide to FI
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