Frequency of Hepatitis C Virus Genotypes in Patients Who Had Hepatocellular Carcinoma in Gastroenterological Hospitals o
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ORIGINAL RESEARCH
Frequency of Hepatitis C Virus Genotypes in Patients Who Had Hepatocellular Carcinoma in Gastroenterological Hospitals of Tabriz Saeed Tarzi 1 & Mahmoud Mansouri 2 & Sahar Pashaei Sarand 3 & Navid Shomali 4,5 & Rozita Tamjidifar 1 & Changiz Ahmadizadeh 1
# Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Background Generally, hepatitis C has been identified as one of the major health issues that about 3% of the world’s population have been threatened and affected by it (about 170 million people), and also, it can be considered a factor in acute and chronic hepatitis. Methods The aim of this study is to determine the prevalence of HCV genotypes in Azerbaijan patients. In this study, sampling was done on the referred patients to the hospitals (Mahallati and Behbud Hospital). RNA was extracted after isolation of plasma, and then, after the synthesizing of cDNA, the sample was carried out to the laboratory for performing the real-time PCR in order to determine the genotypes. Results The evaluation of HCV genotypes in positive plasma samples showed that dominant subsets were remarkable and the mean age of the patients was 37/3 ± 11/8 (in the age range of 2–63). Among the 235 patients,139 of them (59%) were male. Statistically, the average number of women was more than men (T test, P < 0/05). 1b genotype was reported 70% in the patients above 40 years old, and also, it was reported as 71/6% in the patients under 40 years old that was not statistically significant. The incidence of serotype 3a was higher among the patients younger than 40 years old (3a was 18.1% vs. 15%), and this serotype was prevalent among men (3a was 18.7% vs. 14.6%), which was statistically significant. Conclusion The findings indicate that among Azerbaijan’s patients with chronic hepatitis C, genotypes 1b (71.1%) and 3a (17%) were dominant. Keywords Hepatitis C . Hepatocellular carcinoma . Genotype
Background Hepatitis C virus is an infectious disease that is a kind of a single-strand positive RNA virus and the main cause of * Changiz Ahmadizadeh [email protected] 1
Department of Biology Ahar Branch, Islamic Azad University, Ahar, Iran
2
The University of Tehran, Department of Applied Chemistry, Tehran, Iran
3
Amirkabir University of Technology (Polytechnic of Tehran), Department of Applied Chemistry, Tehran, Iran
4
Department of Immunology, Tabriz University of Medical Sciences, Tabriz, Iran
5
Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
liver cirrhosis [1]. It is one of the known agents that affect the normal functioning of the liver and causes acute and chronic infection [2, 3]. Hepatitis C is one of the issues posed by the World Health Organization and threatens about 3% of the world’s total population (approximately 170 million people) [4]. Genotype plays an important role in pathogenesis and hepatitis infection [5]. According to the latest studies, the hepatitis C virus had seven genotypes and at least 67 subsets [6]. In many studies, there is a
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