Frontiers in Microbiology From Antibiotics to AIDS

The International Symposium on Frontiers in Microbiology has been de­ dicated to Prof. P. De Somer, whom I succeeded shortly after his death on 17 June 1985 as Rector of this now more than 560-year old University. When Prof. De Somer became the head of th

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NEW PERSPECTIVES IN CLINICAL MICROBIOLOGY

Brumfitt W, ed Hamilton-Miller JMT, assist. ed: New perspectives in clinical microbiology. 1978. ISBN 90-247-2074-5 Tyrrell DAJ, ed: Aspects of slow and persistent virus infections. 1979. ISBN 90-247-2281-0 Brumfitt W, Curcio L, Silvestri L, eds: Combined antimicrobial therapy. 1979. ISBN 90-247-2280-2 van Furth R, ed: Developments in antibiotic treatment of respiratory infections. 1981. ISBN 90-247-2493-7 van Furth R, ed: Evaluation and management of hospital infections. 1982. ISBN 90-247-2754-5 Kuwahara S, Pierce NF, eds: Advances in research on cholera and related diarrheas 1. 1983. ISBN 0-89838-592-X Ristic M, Ambroise-Thomas P, Kreier J, eds: Malaria and babesiosis: Research findings and control measures. 1984. ISBN 0-89838-675-6 Kuwahara S, Pierce NF, eds: Advances in research on cholera and related diarrheas 2. 1984. ISBN 0-89838-680-2 Takeda Y: Bacterial diarrheal diseases. 1984. ISBN 0-89838-681-0 Hill MJ, Borriello SP, Hardie JM, Hudson MJ, Lysons RJ, Tabaqchali S, eds: Models of anaerobic infection. 1984. ISBN 0-89838-688-8 Taylor-Robinson D, ed: Clinical problems in sexually transmitted diseases. 1985. ISBN 0-89838-720-5 Borriello SP, Hardie JM, Drasar BS, Duerden BI, Hudson MJ, Lysons RJ, eds: Recent advances in anaerobic bacteriology. 1987. ISBN 0-89838-847-3 de Clercq E, ed: Frontiers in microbiology. 1987. ISBN 0-89838-959-3

FRONTIERS IN MICROBIOLOGY From Antibiotics to AIDS

editor:

ERIK DE CLERCQ Rega Institute, Department oj Microbiology and Biochemistry, School oj Medicine, Katholieke Universiteit Leuven, Belgium

1987

MARTINUS NIJHOFF PUBLISHERS

a member of the KLUWER ACADEMIC PUBLISHERS GROUP

DORDRECHT / BOSTON / LANCASTER

Distributors

for the United States and Canada: Kluwer Academic Publishers, P.O. Box 358, Accord Station, Hingham, MA 02018-0358, USA for the UK and Ireland: Kluwer Academic Publishers, MTP Press Limited, Falcon House, Queen Square, Lancaster LA1 1RN, UK for all other countries: Kluwer Academic Publishers Group, Distribution Center, P.O. Box 322, 3300 AH Dordrecht, The Netherlands

Library of Congress Cataloging in Publication Data Frontiers in microbiology. (New perspectives in clinical microbiology) Proceedings of the International Symposium on Frontiers in Microbiology, held Nov. 1986 in Leuven, and sponsored by the National Fonds voor Wetenschappelijk Onderzoek and other organizations. 1. Medical microbiology--Congresses. I. De Clercq, Erik. II. International Symposium on Frontiers in Hic:robiology (1986 : Louvain, Belgium) III. Fonds national de la recherche scientificqu (Belgium) IV. Series. [DNLH: 1. Allergy and Immunology--congresses. 2. Hicrobiology--congresses. 3. Virology--congresses. QW 4 F935 1986] 616' .01 87-18548 QR46.F798 1987

ISBN-13: 978-94-010-8006-4 e-ISBN-13: 978-94-009-3353-8 001: 10.1007/978-94-009-3353-8 Copyright

© 1987 by Martinus Nijhoff Publishers, Dordrecht. Softcover reprint of the hardcover 1st edition 1987 All rights reserved. No part of this publication may be reproduced, stored in a retr