Marburg- and Ebolaviruses From Ecosystems to Molecules

This volume provides an overview of recent advances in our understanding of the biology of marburg- and ebolaviruses. It focuses on four essential areas: 1) ecology, outbreaks and clinical management, 2) disease, pathogenesis and protection, 3) virus repl

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Elke Mühlberger Lisa L. Hensley Jonathan S. Towner Editors

Marburgand Ebolaviruses From Ecosystems to Molecules

Current Topics in Microbiology and Immunology Volume 411

Series editors Rafi Ahmed School of Medicine, Rollins Research Center, Emory University, Room G211, 1510 Clifton Road, Atlanta, GA 30322, USA Klaus Aktories Medizinische Fakultät, Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Abt. I, Albert-Ludwigs-Universität Freiburg, Albertstr. 25, 79104, Freiburg, Germany Arturo Casadevall W. Harry Feinstone Department of Molecular Microbiology & Immunology, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Room E5132, Baltimore, MD 21205, USA Richard W. Compans Department of Microbiology and Immunology, Emory University, 1518 Clifton Road, CNR 5005, Atlanta, GA 30322, USA Jorge E. Galan Boyer Ctr. for Molecular Medicine, School of Medicine, Yale University, 295 Congress Avenue, room 343, New Haven, CT 06536-0812, USA Adolfo Garcia-Sastre Icahn School of Medicine at Mount Sinai, Department of Microbiology, 1468 Madison Ave., Box 1124, New York, NY 10029, USA Tasuku Honjo Faculty of Medicine, Department of Medical Chemistry, Kyoto University, Sakyo-ku, Yoshida, Kyoto, 606-8501, Japan Bernard Malissen Centre d’Immunologie de Marseille-Luminy, Parc Scientifique de Luminy, Case 906, 13288, Marseille Cedex 9, France Klaus Palme Institute of Biology II/Molecular Plant Physiology, Albert-Ludwigs-Universität Freiburg, 79104, Freiburg, Germany Rino Rappuoli GSK Vaccines, Via Fiorentina 1, Siena, 53100, Italy

Honorary editors Michael B. A. Oldstone Department of Immunology and Microbiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA Peter K. Vogt Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, BCC-239, La Jolla, CA 92037, USA

More information about this series at http://www.springer.com/series/82

Elke Mühlberger Lisa L. Hensley Jonathan S. Towner •

Editors

Marburg- and Ebolaviruses From Ecosystems to Molecules Responsible series editor: Yoshihiro Kawaoka

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Editors Elke Mühlberger Boston University School of Medicine Boston, MA USA

Jonathan S. Towner Centers for Disease Control and Prevention Atlanta, GA USA

Lisa L. Hensley NIAID National Institutes of Health Frederick, MD USA

ISSN 0070-217X ISSN 2196-9965 (electronic) Current Topics in Microbiology and Immunology ISBN 978-3-319-68946-3 ISBN 978-3-319-68948-7 (eBook) https://doi.org/10.1007/978-3-319-68948-7 Library of Congress Control Number: 2017960183 © Springer International Publishing AG (outside the USA) 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by s