Hepatitis C Virus I Cellular and Molecular Virology
This volume is composed of chapters that review important fundamental aspects of HCV biology and disease pathogenesis including, for example, the discovery and identification of the HCV genome, early virus-cell interactions including identification of var
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s C Virus I Cellular and Molecular Virology
Hepatitis C Virus I
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Tatsuo Miyamura • Stanley M. Lemon • Christopher M. Walker • Takaji Wakita Editors
Hepatitis C Virus I Cellular and Molecular Virology
Editors Tatsuo Miyamura National Institute of Infectious Diseases Tokyo, Japan
Christopher M. Walker Center for Vaccines and Immunity The Research Institute at Nationwide Children’s Hospital Columbus, Ohio USA
Stanley M. Lemon Departments of Medicine and Microbiology & Immunology The University of North Carolina Chapel Hill, North Carolina USA Takaji Wakita National Institute of Infectious Diseases Tokyo, Japan
ISBN 978-4-431-56096-8 ISBN 978-4-431-56098-2 DOI 10.1007/978-4-431-56098-2
(eBook)
Library of Congress Control Number: 2016951214 © Springer Japan 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer Japan KK
Contents
Part I
Hepatitis C Virus
Towards the Control of Hepatitis C . . . . . . . . . . . . . . . . . . . . . . . . . . . . Michael Houghton
3
Hepatitis C Virus Genotypes and Their Evolution . . . . . . . . . . . . . . . . . Tadasu Shin-I, Masaya Sugiyama, and Masashi Mizokami
15
The Structure of HCV . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Joseph Marcotrigiano and Maria Teresa Catanese
31
Part II
The Viral Life Cycle
Cell Culture Systems for Propagation of HCV . . . . . . . . . . . . . . . . . . . . Takaji Wakita
67
HCV Receptors and Virus Entry . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Rajiv G. Tawar, Catherine Schuster, and Thomas F. Baumert
81
Structural Proteins of HCV and Biological Functions . . . . . . . . . . . . . . 105 Kohji Moriishi and Yoshiharu Matsuura Role of Nonstructural Proteins in HCV Replication . . . . . . . . . . . . . . . . 129 Tetsuro Suzuki and Ryosuke Suzuki The HCV Replicase Complex and Viral RNA Synthesis . . . . . . .
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