Isolation and evaluation of trypanocidal activity of sesquiterpenoids, flavonoids, and lignans in Artemisia sieversiana
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ORIGINAL PAPER
Isolation and evaluation of trypanocidal activity of sesquiterpenoids, flavonoids, and lignans in Artemisia sieversiana collected in Mongolia Stipan Nurbek1 · Toshihiro Murata2 · Keisuke Suganuma3 · Yoshinobu Ishikawa4 · Buyanmandakh Buyankhishig2 · Takashi Kikuchi5 · Tseesuren Byambajav6 · Bekh‑Ochir Davaapurev1 · Kenroh Sasaki2 · Javzan Batkhuu1 Received: 14 May 2020 / Accepted: 22 June 2020 © The Japanese Society of Pharmacognosy 2020
Abstract Artemisia sieversiana is an annual herbaceous plant distributed throughout Central and East Eurasia and is regarded as an undesirable forage plant in Mongolia. It affects livestock, so information about its chemical composition is needed. We isolated three new sesquiterpenoids (1–3) and known compounds from A. sieversiana and investigated their activities. The absolute configuration of 1 was established using single-crystal X-ray diffraction crystallography, and its configuration differed from those of reported compounds with similar structures. Two additional new sesquiterpenoids (2 and 3) with similar structures were identified, and their configurations were determined. The trypanocidal activities of the isolated compounds (1–18) against Trypanosoma congolense and the pathogen responsible for fatal trypanosomosis in animals were estimated. Flavonoids and lignans were identified as active compounds with IC50 values ranging from 2.9 to 90.2 µM Graphic abstract
Keywords Artemisia sieversiana · Compositae · Sesquiterpenoid · Lignan · Polymethoxyflavonoid · Trypanosoma congolense Electronic supplementary material The online version of this article (https://doi.org/10.1007/s11418-020-01429-2) contains supplementary material, which is available to authorized users. * Toshihiro Murata murata‑t@tohoku‑mpu.ac.jp
4
University of Shizuoka, Shizuoka, Japan
5
Rigaku Corporation, Tokyo, Japan
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Institute of Veterinary Medicine, Mongolian University of Life Sciences, Ulaanbaatar, Mongolia
National University of Mongolia, Ulaanbaatar, Mongolia
2
Department of Pharmacognosy, Tohoku Medical and Pharmaceutical University, 4‑1 Komatsushima 4‑chome, Aoba‑ku, Sendai 981‑8558, Japan
3
National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan
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Introduction Artemisia sieversiana Ehrh. ex willd. (Compositae) is an annual herbaceous plant distributed throughout Central and East Eurasia. It is a traditional medicinal plant in parts of Asia, including Tibet, China, and Mongolia. The flowers of A. sieversiana are used to treat fevers, throat inflammation, and pneumonia in Mongolia [1], where it is commonly known as tsarvant sharilj. It is an important edible plant for nomadic Mongolian livestock, and it is most palatable to camel, goat, and sheep in spring. Livestock does not consume A. sieversiana during the summer, although they resume consumption in autumn [2]. Nomadic people have noted that livestock produces milk with an unpleasant odor and flavor a
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